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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968473363> ?p ?o ?g. }

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• W2968473363 abstract "microRNA-496 (miR-496) was found expressed abnormally in non-small cell lung cancer (NSCLC). But the study about the role of miR-496 on NSCLC was not satisfactory in date. Therefore, here we designed to explore the role of miR-496 and the probable internal mechanism in tumorigenesis of NSCLC. Increasing miR-496 both in NSCLC patients and cell lines could significantly restrained cell proliferation. For farther researching the regulation mechanism of miR-496 on NSCLC, we screen Brain derived neurotrophic factor (BDNF) as a potential target of miR-496 by bioinformatic methods and predicted a possible target of miR-496 in the 3′untranslated region (UTR) of miR-496. In clinical patients and most NSCLC cell lines including H1650, H292, H1944 and A549, increasing expression of miR-496 suppressed tumor growth via inactivating BDNF-mediated PI3K/Akt signaling pathway activation. In a word, our fingdings first represent a mechanism of miR-496 on NSCLC tumor growth via inactivating BDNF-mediated PI3K/Akt signaling pathway." @default.
• W2968473363 created "2019-08-22" @default.
• W2968473363 creator A5028533482 @default.
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• W2968473363 date "2019-10-01" @default.
• W2968473363 modified "2023-10-17" @default.
• W2968473363 title "miR-496 suppress tumorigenesis via targeting BDNF-mediated PI3K/Akt signaling pathway in non-small cell lung cancer" @default.
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• W2968473363 doi "https://doi.org/10.1016/j.bbrc.2019.08.046" @default.
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