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• W2968474902 abstract "The effect of miR‑124 on the proliferation and differentiation of brain glioma stem cells and Nogo/NgR signaling pathway were investigated. miR‑124 mimic, miR‑124 inhibitor and miR‑control expression vector were designed and produced to transfect U87 glioma stem cells. The results of transfection were tested via RT‑qPCR and the expression of protein was detected by western blot analysis. Cell proliferation was detected by MTT proliferation and the proportion of CD133+ cells was detected by immunomagnetic beads to determine cell differentiation. The correlation between miR‑124 and Nogo‑A, and NgR protein expression was analyzed by Spearman correlation analysis. The relative expression of miR‑124 in cells of miR‑124 mimic group was significantly higher than that of miR‑124 inhibitor and miR‑control groups (P<0.05). The relative expression of Nogo‑A and NgR protein in cells of the miR‑124 mimic group was significantly lower than that of miR‑124 inhibitor and miR‑control groups (P<0.05). Absorbance values of the cells in the miR‑124 mimic and miR‑control groups were significantly lower than those in the miR‑124 inhibitor group at each time point (P<0.05), while the values of the cells in the miR‑124 mimic group were significantly lower than that in miR‑control group (P<0.05). The level of CD133+ cells in miR‑124 mimic group was significantly lower than that in miR‑124 inhibitor and miR‑control groups (P<0.05), while the level of CD133+ cells in miR‑124 inhibitor group was higher than that in miR‑control group (P<0.05). Correlation analysis revealed that there was a negative correlation between miR‑124 and the expression of Nogo‑A and NgR protein (P<0.05). miR‑124 may participate in the differentiation of brain glioma stem cells through the Nogo/NgR pathway, which may bring a new direction for the clinical treatment of brain glioma." @default.
• W2968474902 created "2019-08-22" @default.
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• W2968474902 date "2019-08-16" @default.
• W2968474902 modified "2023-09-24" @default.
• W2968474902 title "miR‑124 participates in the proliferation and differentiation of brain glioma stem cells through regulating Nogo/NgR expression" @default.
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• W2968474902 doi "https://doi.org/10.3892/etm.2019.7914" @default.
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