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• W2968479826 abstract "Acinetobacter baumannii is currently considered one of the most problematic nosocomial microorganisms. In the present work the hisF gene from the ATCC 17978 strain and the AbH12O-A2 clinical isolate of A. baumannii was found over-expressed during the course of murine pneumonia infections. The study demonstrated that the A. baumannii ATCC 17978 mutant strain lacking the hisF gene induces a sub-lethal pneumonia infection in mice, while the complemented mutant strain increased its virulence. This histidine auxotroph mutant showed an increase on IL-6 secretion and leukocytes recruitment during infections. Furthermore, data revealed that the hisF gene, implicated in the innate immunity and inflammation, is involved in virulence during a pneumonia infection, which may partly explain the ability of this strain to persist in the lung. We suggest that HisF, essential for full virulence in this pathogen, should be considered a potential target for developing new antimicrobial therapies against A. baumannii." @default.
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• W2968479826 date "2019-08-29" @default.
• W2968479826 modified "2023-10-15" @default.
• W2968479826 title "Involvement of HisF in the Persistence of Acinetobacter baumannii During a Pneumonia Infection" @default.
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• W2968479826 doi "https://doi.org/10.3389/fcimb.2019.00310" @default.
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