FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968483144> ?p ?o ?g. }

• W2968483144 endingPage "927" @default.
• W2968483144 startingPage "916" @default.
• W2968483144 abstract "Pelvic organ prolapse (POP) in lysyl oxidase like-1 knockout (Loxl1 KO) mice occurs primarily in parous mice and is rare in nulliparous mice. We determined the effect of Loxl1 deficiency on postpartum regulation of connective tissue metabolism genes and degradative enzyme activity in the vagina at 20 days gestation or 4 h, 48 h, 7 days, 15 days, 25 days, 7 weeks, or 12 weeks postpartum. Nulliparous Loxl1 KO and wildtype (WT) mice aged 11, 18, or 23 weeks were controls. Gene expression and enzyme activity were assessed using real-time quantitative reverse transcription PCR and fluorescein conjugated gelatin zymography, respectively. Parity, but not aging, had a significant influence on gene expression both with time postpartum and between KO and WT mice. Mmp2, Timp1, Timp2, Timp3, Timp4, Col1a1, Col3a1, Acta2, and Bmp1 were differentially expressed between KO and WT mice. Correlational analysis of gene-gene pairs revealed 10 significant differences between parous KO and WT groups, 5 of which were due to lack of co-expression of Bmp1 in KO mice. The overall enzyme activity that could be attributed to MMPs was significantly higher in WT compared to KO mice both 25 days and 12 weeks postpartum, and MMP activity was significantly lower 15 days and 25 days postpartum compared to KO nulliparous controls, but not WT. These findings suggest that Loxl1 deficiency combined with parity has a significant impact on postpartum regulation of connective tissue metabolism, particularly as it relates to co-expression of Bmp1 and altered proteolytic activity." @default.
• W2968483144 created "2019-08-22" @default.
• W2968483144 creator A5017579123 @default.
• W2968483144 creator A5035254763 @default.
• W2968483144 creator A5056919862 @default.
• W2968483144 creator A5065360308 @default.
• W2968483144 creator A5069259268 @default.
• W2968483144 date "2019-08-12" @default.
• W2968483144 modified "2023-09-26" @default.
• W2968483144 title "Role of lysyl oxidase like 1 in regulation of postpartum connective tissue metabolism in the mouse vagina†" @default.
• W2968483144 cites W141288945 @default.
• W2968483144 cites W146516613 @default.
• W2968483144 cites W1499476232 @default.
• W2968483144 cites W1535684291 @default.
• W2968483144 cites W1540618782 @default.
• W2968483144 cites W1572793678 @default.
• W2968483144 cites W1594987801 @default.
• W2968483144 cites W1833314573 @default.
• W2968483144 cites W1910308666 @default.
• W2968483144 cites W1963633579 @default.
• W2968483144 cites W1964216105 @default.
• W2968483144 cites W1966538528 @default.
• W2968483144 cites W1971804064 @default.
• W2968483144 cites W1972200316 @default.
• W2968483144 cites W1977701075 @default.
• W2968483144 cites W1980730885 @default.
• W2968483144 cites W1988467290 @default.
• W2968483144 cites W1988888423 @default.
• W2968483144 cites W1998429750 @default.
• W2968483144 cites W2004880306 @default.
• W2968483144 cites W2006353424 @default.
• W2968483144 cites W2007981437 @default.
• W2968483144 cites W2009785563 @default.
• W2968483144 cites W2009869955 @default.
• W2968483144 cites W2014280470 @default.
• W2968483144 cites W2014763555 @default.
• W2968483144 cites W2015635389 @default.
• W2968483144 cites W2019002861 @default.
• W2968483144 cites W2024578195 @default.
• W2968483144 cites W2033753997 @default.
• W2968483144 cites W2035683946 @default.
• W2968483144 cites W2038725101 @default.
• W2968483144 cites W2044261760 @default.
• W2968483144 cites W205288085 @default.
• W2968483144 cites W2060110177 @default.
• W2968483144 cites W2062809449 @default.
• W2968483144 cites W2064321131 @default.
• W2968483144 cites W2065398044 @default.
• W2968483144 cites W2076636789 @default.
• W2968483144 cites W2079603754 @default.
• W2968483144 cites W2080066082 @default.
• W2968483144 cites W2083339623 @default.
• W2968483144 cites W2119231122 @default.
• W2968483144 cites W2124492445 @default.
• W2968483144 cites W2128380029 @default.
• W2968483144 cites W2130894316 @default.
• W2968483144 cites W2134652066 @default.
• W2968483144 cites W2134903396 @default.
• W2968483144 cites W2139149436 @default.
• W2968483144 cites W2144582380 @default.
• W2968483144 cites W2144814098 @default.
• W2968483144 cites W2146275594 @default.
• W2968483144 cites W2164692123 @default.
• W2968483144 cites W2166219269 @default.
• W2968483144 cites W2318084145 @default.
• W2968483144 cites W2402471166 @default.
• W2968483144 cites W2408449031 @default.
• W2968483144 cites W2476542314 @default.
• W2968483144 cites W2520198559 @default.
• W2968483144 cites W4297723481 @default.
• W2968483144 cites W2005737509 @default.
• W2968483144 doi "https://doi.org/10.1093/biolre/ioz148" @default.
• W2968483144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7245155" @default.
• W2968483144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31403161" @default.
• W2968483144 hasPublicationYear "2019" @default.
• W2968483144 type Work @default.
• W2968483144 sameAs 2968483144 @default.
• W2968483144 citedByCount "8" @default.
• W2968483144 countsByYear W29684831442020 @default.
• W2968483144 countsByYear W29684831442021 @default.
• W2968483144 countsByYear W29684831442022 @default.
• W2968483144 countsByYear W29684831442023 @default.
• W2968483144 crossrefType "journal-article" @default.
• W2968483144 hasAuthorship W2968483144A5017579123 @default.
• W2968483144 hasAuthorship W2968483144A5035254763 @default.
• W2968483144 hasAuthorship W2968483144A5056919862 @default.
• W2968483144 hasAuthorship W2968483144A5065360308 @default.
• W2968483144 hasAuthorship W2968483144A5069259268 @default.
• W2968483144 hasBestOaLocation W29684831441 @default.
• W2968483144 hasConcept C104317684 @default.
• W2968483144 hasConcept C105702510 @default.
• W2968483144 hasConcept C109523444 @default.
• W2968483144 hasConcept C126322002 @default.
• W2968483144 hasConcept C134018914 @default.
• W2968483144 hasConcept C150194340 @default.
• W2968483144 hasConcept C16685009 @default.
• W2968483144 hasConcept C177430391 @default.
• W2968483144 hasConcept C181199279 @default.

• next