FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968489473> ?p ?o ?g. }

• W2968489473 endingPage "133907" @default.
• W2968489473 startingPage "133907" @default.
• W2968489473 abstract "Polyfluoroalkyl phosphate esters (PAPs) are one kind of emerging polyfluoroalkyl substances in the environment. However, their in vivo toxicities are largely unknown, especially at environmental relevant concentrations. To fill this gap, zebrafish embryos were exposed to 6:2 or 8:2 diPAP at environmentally relevant concentrations (0.5, 5, 50 ng/L) for 7 d. 6:2 and 8:2 diPAPs upregulated the mRNA and protein levels of aromatase in the exposed larvae, and elevated estradiol (E2) and vitellogenin (VTG) levels, but reduced testosterone (T) and 11-ketotestosterone (11-KT) levels, demonstrating estrogenic and antiandrogenic effects. Among the three ER subtypes, ERβ2 displayed the highest in vivo mRNA expression and the lowest in silico binding energies, suggesting that it was the main target ER subtype responsible for the estrogenic effect. Molecular simulation results indicated that diPAPs and E2 could bind to one common residue, arginine (Arg) 87, in the binding pocket of ERβ2, inducing similar estrogenic disruption mechanisms as E2. Both compounds could form hydrophobic interaction with glutamic acid (Glu) 12 and tryptophan (Trp) 80 and two hydrogen bonds with Arg81 of androgen receptor (AR) ligand-binding domains (LBDs) in antagonistic mode, resulting in a reduced level of AR upon exposure. The in silico binding energies of 6:2 diPAP with both ER and AR were lower than 8:2 diPAP, explaining the observed greater in vivo estrogenic and antiandrogenic activities of 6:2 diPAP. This study provided the first line of evidences that diPAPs could display adverse effects on the endocrine functions of fish species." @default.
• W2968489473 created "2019-08-22" @default.
• W2968489473 creator A5000093173 @default.
• W2968489473 creator A5038110820 @default.
• W2968489473 creator A5041421492 @default.
• W2968489473 creator A5044294158 @default.
• W2968489473 creator A5051990971 @default.
• W2968489473 creator A5058696568 @default.
• W2968489473 creator A5074112736 @default.
• W2968489473 date "2019-12-01" @default.
• W2968489473 modified "2023-10-14" @default.
• W2968489473 title "Stronger estrogenic and antiandrogenic effects on zebrafish larvae displayed by 6:2 polyfluoroalkyl phosphate diester than the 8:2 congener at environmentally relevant concentrations" @default.
• W2968489473 cites W1500263261 @default.
• W2968489473 cites W1965926566 @default.
• W2968489473 cites W1980138755 @default.
• W2968489473 cites W1985269661 @default.
• W2968489473 cites W2000089305 @default.
• W2968489473 cites W2006138763 @default.
• W2968489473 cites W2016572372 @default.
• W2968489473 cites W2024698672 @default.
• W2968489473 cites W2029552542 @default.
• W2968489473 cites W2048454218 @default.
• W2968489473 cites W2054731547 @default.
• W2968489473 cites W2074232034 @default.
• W2968489473 cites W2077104587 @default.
• W2968489473 cites W2081560149 @default.
• W2968489473 cites W2084310233 @default.
• W2968489473 cites W2084818336 @default.
• W2968489473 cites W2091046509 @default.
• W2968489473 cites W2101738855 @default.
• W2968489473 cites W2105029818 @default.
• W2968489473 cites W2105575226 @default.
• W2968489473 cites W2108275538 @default.
• W2968489473 cites W2125624687 @default.
• W2968489473 cites W2140633565 @default.
• W2968489473 cites W2140858853 @default.
• W2968489473 cites W2144288821 @default.
• W2968489473 cites W2155651940 @default.
• W2968489473 cites W2160544821 @default.
• W2968489473 cites W2197983629 @default.
• W2968489473 cites W2212308839 @default.
• W2968489473 cites W2332158714 @default.
• W2968489473 cites W2332224743 @default.
• W2968489473 cites W2345417932 @default.
• W2968489473 cites W2345562900 @default.
• W2968489473 cites W2403157581 @default.
• W2968489473 cites W2493857981 @default.
• W2968489473 cites W2514404944 @default.
• W2968489473 cites W2545911900 @default.
• W2968489473 cites W2743893605 @default.
• W2968489473 cites W2750083182 @default.
• W2968489473 cites W2765231636 @default.
• W2968489473 cites W2771129185 @default.
• W2968489473 cites W2782102279 @default.
• W2968489473 cites W2793283003 @default.
• W2968489473 cites W2794857760 @default.
• W2968489473 cites W2795734533 @default.
• W2968489473 cites W2871403286 @default.
• W2968489473 cites W2892210814 @default.
• W2968489473 cites W2894189822 @default.
• W2968489473 cites W2898633268 @default.
• W2968489473 cites W2901455493 @default.
• W2968489473 cites W2909504601 @default.
• W2968489473 cites W2951231225 @default.
• W2968489473 doi "https://doi.org/10.1016/j.scitotenv.2019.133907" @default.
• W2968489473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31425999" @default.
• W2968489473 hasPublicationYear "2019" @default.
• W2968489473 type Work @default.
• W2968489473 sameAs 2968489473 @default.
• W2968489473 citedByCount "11" @default.
• W2968489473 countsByYear W29684894732020 @default.
• W2968489473 countsByYear W29684894732021 @default.
• W2968489473 countsByYear W29684894732022 @default.
• W2968489473 countsByYear W29684894732023 @default.
• W2968489473 crossrefType "journal-article" @default.
• W2968489473 hasAuthorship W2968489473A5000093173 @default.
• W2968489473 hasAuthorship W2968489473A5038110820 @default.
• W2968489473 hasAuthorship W2968489473A5041421492 @default.
• W2968489473 hasAuthorship W2968489473A5044294158 @default.
• W2968489473 hasAuthorship W2968489473A5051990971 @default.
• W2968489473 hasAuthorship W2968489473A5058696568 @default.
• W2968489473 hasAuthorship W2968489473A5074112736 @default.
• W2968489473 hasConcept C104317684 @default.
• W2968489473 hasConcept C121608353 @default.
• W2968489473 hasConcept C126322002 @default.
• W2968489473 hasConcept C134018914 @default.
• W2968489473 hasConcept C150903083 @default.
• W2968489473 hasConcept C185592680 @default.
• W2968489473 hasConcept C207001950 @default.
• W2968489473 hasConcept C2779078696 @default.
• W2968489473 hasConcept C2780192828 @default.
• W2968489473 hasConcept C2780862370 @default.
• W2968489473 hasConcept C46699223 @default.
• W2968489473 hasConcept C526171541 @default.
• W2968489473 hasConcept C530470458 @default.
• W2968489473 hasConcept C55493867 @default.
• W2968489473 hasConcept C61367390 @default.
• W2968489473 hasConcept C62231903 @default.

• next