Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968505655> ?p ?o ?g. }
- W2968505655 endingPage "645" @default.
- W2968505655 startingPage "636" @default.
- W2968505655 abstract "This review provides an update on definitions of chronicity of infection, approaches to airway sampling to detect infection, strategies for Pseudomonas aeruginosa eradication, impact of cystic fibrosis transmembrane regulator protein (CFTR) modulators and future challenges for clinical trials.Rates of P. aeruginosa have decreased over the past two decades with establishment of effective eradication protocols. Definitions of chronic P. aeruginosa infection have required adaptation for healthier populations. Although molecular (PCR) approaches to early P. aeruginosa detection are sensitive, to date, earlier diagnosis has not impacted on clinical outcomes. Despite eradication regimens, some people with early P. aeruginosa fail to clear their infection. Most people also experience a recurrence and eventual transition to chronic infection. Several recent studies sought to address this gap. CFTR modulators (predominantly ivacaftor) demonstrated reduced P. aeruginosa density, although infection may persist or recur demonstrating the need for continued antiinfective therapies in the modulator era.Future studies of approaches to P. aeruginosa eradication will be complex due to expanded availability and ongoing competitive clinical trials of CFTR modulators. Studies to address optimal eradication therapy, particularly in adults, will be required, though adequate recruitment to power these studies may prove challenging." @default.
- W2968505655 created "2019-08-22" @default.
- W2968505655 creator A5000108930 @default.
- W2968505655 creator A5020072100 @default.
- W2968505655 date "2019-11-01" @default.
- W2968505655 modified "2023-10-18" @default.
- W2968505655 title "Prevention of chronic infection with Pseudomonas aeruginosa infection in cystic fibrosis" @default.
- W2968505655 cites W1521667132 @default.
- W2968505655 cites W1954257474 @default.
- W2968505655 cites W1971558827 @default.
- W2968505655 cites W1988363871 @default.
- W2968505655 cites W1996632302 @default.
- W2968505655 cites W2034083161 @default.
- W2968505655 cites W2051836609 @default.
- W2968505655 cites W2060657293 @default.
- W2968505655 cites W2086235445 @default.
- W2968505655 cites W2090648579 @default.
- W2968505655 cites W2095687634 @default.
- W2968505655 cites W2100164793 @default.
- W2968505655 cites W2101012696 @default.
- W2968505655 cites W2109939030 @default.
- W2968505655 cites W2115154958 @default.
- W2968505655 cites W2115591045 @default.
- W2968505655 cites W2128677706 @default.
- W2968505655 cites W2140868856 @default.
- W2968505655 cites W2142641193 @default.
- W2968505655 cites W2143694083 @default.
- W2968505655 cites W2144101090 @default.
- W2968505655 cites W2153102800 @default.
- W2968505655 cites W2154399253 @default.
- W2968505655 cites W2155069031 @default.
- W2968505655 cites W2166779461 @default.
- W2968505655 cites W2168898577 @default.
- W2968505655 cites W2236839872 @default.
- W2968505655 cites W2250182074 @default.
- W2968505655 cites W2253886635 @default.
- W2968505655 cites W2280524460 @default.
- W2968505655 cites W2344806786 @default.
- W2968505655 cites W2415314565 @default.
- W2968505655 cites W2506782367 @default.
- W2968505655 cites W2560268125 @default.
- W2968505655 cites W2586839394 @default.
- W2968505655 cites W2589766919 @default.
- W2968505655 cites W2736699990 @default.
- W2968505655 cites W2763234158 @default.
- W2968505655 cites W2765148073 @default.
- W2968505655 cites W2782476820 @default.
- W2968505655 cites W2782942711 @default.
- W2968505655 cites W2789525784 @default.
- W2968505655 cites W2789687868 @default.
- W2968505655 cites W2796806254 @default.
- W2968505655 cites W2796938658 @default.
- W2968505655 cites W2802582670 @default.
- W2968505655 cites W2803635395 @default.
- W2968505655 cites W2808658611 @default.
- W2968505655 cites W2810931978 @default.
- W2968505655 cites W2887334699 @default.
- W2968505655 cites W2887630310 @default.
- W2968505655 cites W2888562344 @default.
- W2968505655 cites W2888944359 @default.
- W2968505655 cites W2893550035 @default.
- W2968505655 cites W2894022731 @default.
- W2968505655 cites W2894103795 @default.
- W2968505655 cites W2905366614 @default.
- W2968505655 cites W2908863470 @default.
- W2968505655 cites W2909494551 @default.
- W2968505655 cites W2914149338 @default.
- W2968505655 cites W2940998296 @default.
- W2968505655 cites W2947584570 @default.
- W2968505655 cites W4211056322 @default.
- W2968505655 doi "https://doi.org/10.1097/mcp.0000000000000616" @default.
- W2968505655 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8545221" @default.
- W2968505655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31397692" @default.
- W2968505655 hasPublicationYear "2019" @default.
- W2968505655 type Work @default.
- W2968505655 sameAs 2968505655 @default.
- W2968505655 citedByCount "5" @default.
- W2968505655 countsByYear W29685056552020 @default.
- W2968505655 countsByYear W29685056552021 @default.
- W2968505655 countsByYear W29685056552022 @default.
- W2968505655 countsByYear W29685056552023 @default.
- W2968505655 crossrefType "journal-article" @default.
- W2968505655 hasAuthorship W2968505655A5000108930 @default.
- W2968505655 hasAuthorship W2968505655A5020072100 @default.
- W2968505655 hasBestOaLocation W29685056552 @default.
- W2968505655 hasConcept C126322002 @default.
- W2968505655 hasConcept C166888038 @default.
- W2968505655 hasConcept C177713679 @default.
- W2968505655 hasConcept C203014093 @default.
- W2968505655 hasConcept C2776502428 @default.
- W2968505655 hasConcept C2776938444 @default.
- W2968505655 hasConcept C2777637488 @default.
- W2968505655 hasConcept C2778428886 @default.
- W2968505655 hasConcept C3019392825 @default.
- W2968505655 hasConcept C523546767 @default.
- W2968505655 hasConcept C535046627 @default.
- W2968505655 hasConcept C54355233 @default.
- W2968505655 hasConcept C71924100 @default.