FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968607768> ?p ?o ?g. }

• W2968607768 endingPage "1203" @default.
• W2968607768 startingPage "1195" @default.
• W2968607768 abstract "Background Some interstitial lung diseases are associated with lung cancer. However, it is unclear whether asymptomatic interstitial lung abnormalities convey an independent risk. Objectives The goal of this study was to assess whether interstitial lung abnormalities are associated with an increased risk of lung cancer. Methods Data from all participants in the National Lung Cancer Trial were analyzed, except for subjects with preexisting interstitial lung disease or prevalent lung cancers. The primary analysis included those who underwent low-dose CT imaging; those undergoing chest radiography were included in a confirmatory analysis. Participants with evidence of reticular/reticulonodular opacities, honeycombing, fibrosis, or scarring were classified as having interstitial lung abnormalities. Lung cancer incidence and mortality in participants with and without interstitial lung abnormalities were compared by using Poisson and Cox regression, respectively. Results Of the 25,041 participants undergoing low-dose CT imaging included in the primary analysis, 20.2% had interstitial lung abnormalities. Participants with interstitial lung abnormalities had a higher incidence of lung cancer (incidence rate ratio, 1.61; 95% CI, 1.30-1.99). Interstitial lung abnormalities were associated with higher lung cancer incidence on adjusted analyses (incidence rate ratio, 1.33; 95% CI, 1.07-1.65). Lung cancer-specific mortality was also greater in participants with interstitial lung abnormalities. Similar findings were obtained in the analysis of participants undergoing chest radiography. Conclusions Asymptomatic interstitial lung abnormalities are an independent risk factor for lung cancer that can be incorporated into risk score models. Some interstitial lung diseases are associated with lung cancer. However, it is unclear whether asymptomatic interstitial lung abnormalities convey an independent risk. The goal of this study was to assess whether interstitial lung abnormalities are associated with an increased risk of lung cancer. Data from all participants in the National Lung Cancer Trial were analyzed, except for subjects with preexisting interstitial lung disease or prevalent lung cancers. The primary analysis included those who underwent low-dose CT imaging; those undergoing chest radiography were included in a confirmatory analysis. Participants with evidence of reticular/reticulonodular opacities, honeycombing, fibrosis, or scarring were classified as having interstitial lung abnormalities. Lung cancer incidence and mortality in participants with and without interstitial lung abnormalities were compared by using Poisson and Cox regression, respectively. Of the 25,041 participants undergoing low-dose CT imaging included in the primary analysis, 20.2% had interstitial lung abnormalities. Participants with interstitial lung abnormalities had a higher incidence of lung cancer (incidence rate ratio, 1.61; 95% CI, 1.30-1.99). Interstitial lung abnormalities were associated with higher lung cancer incidence on adjusted analyses (incidence rate ratio, 1.33; 95% CI, 1.07-1.65). Lung cancer-specific mortality was also greater in participants with interstitial lung abnormalities. Similar findings were obtained in the analysis of participants undergoing chest radiography. Asymptomatic interstitial lung abnormalities are an independent risk factor for lung cancer that can be incorporated into risk score models." @default.
• W2968607768 created "2019-08-22" @default.
• W2968607768 creator A5004022151 @default.
• W2968607768 creator A5008905381 @default.
• W2968607768 creator A5019337443 @default.
• W2968607768 creator A5033612339 @default.
• W2968607768 creator A5036008725 @default.
• W2968607768 creator A5044165641 @default.
• W2968607768 creator A5048669296 @default.
• W2968607768 creator A5049808872 @default.
• W2968607768 creator A5061233511 @default.
• W2968607768 creator A5062307508 @default.
• W2968607768 date "2019-12-01" @default.
• W2968607768 modified "2023-10-15" @default.
• W2968607768 title "Interstitial Lung Abnormalities and Lung Cancer Risk in the National Lung Screening Trial" @default.
• W2968607768 cites W130099911 @default.
• W2968607768 cites W1546712514 @default.
• W2968607768 cites W1770545381 @default.
• W2968607768 cites W1826107267 @default.
• W2968607768 cites W1976487567 @default.
• W2968607768 cites W1984439708 @default.
• W2968607768 cites W1985846684 @default.
• W2968607768 cites W1987948791 @default.
• W2968607768 cites W1988781537 @default.
• W2968607768 cites W2003254802 @default.
• W2968607768 cites W2005399165 @default.
• W2968607768 cites W2006750439 @default.
• W2968607768 cites W2009183164 @default.
• W2968607768 cites W2010292452 @default.
• W2968607768 cites W2027470652 @default.
• W2968607768 cites W2032894305 @default.
• W2968607768 cites W2042973241 @default.
• W2968607768 cites W2044190108 @default.
• W2968607768 cites W2047783807 @default.
• W2968607768 cites W2067269986 @default.
• W2968607768 cites W2079077297 @default.
• W2968607768 cites W2081772751 @default.
• W2968607768 cites W2087442158 @default.
• W2968607768 cites W2109896839 @default.
• W2968607768 cites W2110573194 @default.
• W2968607768 cites W2117098575 @default.
• W2968607768 cites W2122060090 @default.
• W2968607768 cites W2128955496 @default.
• W2968607768 cites W2133040980 @default.
• W2968607768 cites W2133869810 @default.
• W2968607768 cites W2134242123 @default.
• W2968607768 cites W2136039969 @default.
• W2968607768 cites W2141640110 @default.
• W2968607768 cites W2156215547 @default.
• W2968607768 cites W2160431037 @default.
• W2968607768 cites W2167704143 @default.
• W2968607768 cites W2209011198 @default.
• W2968607768 cites W2215837199 @default.
• W2968607768 cites W2241809628 @default.
• W2968607768 cites W2277604097 @default.
• W2968607768 cites W2306008721 @default.
• W2968607768 cites W2317242858 @default.
• W2968607768 cites W2424800769 @default.
• W2968607768 cites W2512899508 @default.
• W2968607768 cites W2567033333 @default.
• W2968607768 cites W2604950454 @default.
• W2968607768 cites W2754180290 @default.
• W2968607768 cites W2757382816 @default.
• W2968607768 cites W2789636254 @default.
• W2968607768 cites W3023753000 @default.
• W2968607768 cites W774466653 @default.
• W2968607768 doi "https://doi.org/10.1016/j.chest.2019.06.041" @default.
• W2968607768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31404527" @default.
• W2968607768 hasPublicationYear "2019" @default.
• W2968607768 type Work @default.
• W2968607768 sameAs 2968607768 @default.
• W2968607768 citedByCount "53" @default.
• W2968607768 countsByYear W29686077682019 @default.
• W2968607768 countsByYear W29686077682020 @default.
• W2968607768 countsByYear W29686077682021 @default.
• W2968607768 countsByYear W29686077682022 @default.
• W2968607768 countsByYear W29686077682023 @default.
• W2968607768 crossrefType "journal-article" @default.
• W2968607768 hasAuthorship W2968607768A5004022151 @default.
• W2968607768 hasAuthorship W2968607768A5008905381 @default.
• W2968607768 hasAuthorship W2968607768A5019337443 @default.
• W2968607768 hasAuthorship W2968607768A5033612339 @default.
• W2968607768 hasAuthorship W2968607768A5036008725 @default.
• W2968607768 hasAuthorship W2968607768A5044165641 @default.
• W2968607768 hasAuthorship W2968607768A5048669296 @default.
• W2968607768 hasAuthorship W2968607768A5049808872 @default.
• W2968607768 hasAuthorship W2968607768A5061233511 @default.
• W2968607768 hasAuthorship W2968607768A5062307508 @default.
• W2968607768 hasConcept C126322002 @default.
• W2968607768 hasConcept C142724271 @default.
• W2968607768 hasConcept C2776256026 @default.
• W2968607768 hasConcept C2777405583 @default.
• W2968607768 hasConcept C2777543607 @default.
• W2968607768 hasConcept C2777714996 @default.
• W2968607768 hasConcept C2777910003 @default.
• W2968607768 hasConcept C2778341716 @default.
• W2968607768 hasConcept C71924100 @default.
• W2968607768 hasConceptScore W2968607768C126322002 @default.

• next