FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968639985> ?p ?o ?g. }

• W2968639985 endingPage "928" @default.
• W2968639985 startingPage "921" @default.
• W2968639985 abstract "Introduction: Allergen bioavailability underpins the efficacy and safety of SLIT tablets. Three product-related factors are likely to influence this: tablet potency, formulation and sublingual holding time.Areas covered: Tablet formulation determines the rate and extent of solubilized allergen release. Using validated in vitro dissolution assays, the two licensed grass pollen SLIT tablets are shown to release ≥85% of their total allergenic activity within several minutes. Sublingual holding time affects the contact duration between solubilized allergens and sublingual tissue. Maximal uptake of allergens by sublingual tissue requires ~5 minutes, with little uptake occurring within the first minute. A higher potency tablet with longer sublingual holding time would provide higher bioavailability, while faster rates of allergen release in vitro are unlikely to translate to a greater increase in bioavailability. Differences in dissolution times cannot serve as a surrogate of in vivo bioavailability, and are not related to differences in efficacy at the marketed tablet dosages. Rapid in vitro dissolution is likely not a key requirement for inducing a potent immune response.Expert opinion: In vitro dissolution cannot predict the clinical efficacy of SLIT tablets but could be important in immune tolerance and safety. In addition, a discontinuous administration regimen may have benefits for adherence and cost without compromising efficacy." @default.
• W2968639985 created "2019-08-22" @default.
• W2968639985 creator A5015300055 @default.
• W2968639985 creator A5025157783 @default.
• W2968639985 creator A5030629710 @default.
• W2968639985 creator A5032192154 @default.
• W2968639985 creator A5032786189 @default.
• W2968639985 creator A5058240991 @default.
• W2968639985 creator A5069959810 @default.
• W2968639985 creator A5073839386 @default.
• W2968639985 creator A5083725831 @default.
• W2968639985 date "2019-08-12" @default.
• W2968639985 modified "2023-10-18" @default.
• W2968639985 title "Clinical efficacy of sublingual immunotherapy tablets for allergic rhinitis is unlikely to be derived from <i>in vitro</i> allergen-release data" @default.
• W2968639985 cites W1583008465 @default.
• W2968639985 cites W1964513777 @default.
• W2968639985 cites W1967184181 @default.
• W2968639985 cites W1981112907 @default.
• W2968639985 cites W1983153600 @default.
• W2968639985 cites W1989200123 @default.
• W2968639985 cites W2011079863 @default.
• W2968639985 cites W2013737474 @default.
• W2968639985 cites W2028280773 @default.
• W2968639985 cites W2028803867 @default.
• W2968639985 cites W2031803192 @default.
• W2968639985 cites W2038239094 @default.
• W2968639985 cites W2040637363 @default.
• W2968639985 cites W2050878075 @default.
• W2968639985 cites W205383838 @default.
• W2968639985 cites W2053968592 @default.
• W2968639985 cites W2054385168 @default.
• W2968639985 cites W2064924979 @default.
• W2968639985 cites W2074474404 @default.
• W2968639985 cites W2087442940 @default.
• W2968639985 cites W2091909807 @default.
• W2968639985 cites W2093112435 @default.
• W2968639985 cites W2098913651 @default.
• W2968639985 cites W2114743889 @default.
• W2968639985 cites W2121760095 @default.
• W2968639985 cites W2140496197 @default.
• W2968639985 cites W2153589092 @default.
• W2968639985 cites W2164416536 @default.
• W2968639985 cites W2205697295 @default.
• W2968639985 cites W2256659961 @default.
• W2968639985 cites W2394696912 @default.
• W2968639985 cites W2404553274 @default.
• W2968639985 cites W2618410369 @default.
• W2968639985 cites W2760148976 @default.
• W2968639985 cites W2794407266 @default.
• W2968639985 cites W2921288370 @default.
• W2968639985 cites W2921481076 @default.
• W2968639985 cites W2947653195 @default.
• W2968639985 doi "https://doi.org/10.1080/1744666x.2019.1649597" @default.
• W2968639985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31403823" @default.
• W2968639985 hasPublicationYear "2019" @default.
• W2968639985 type Work @default.
• W2968639985 sameAs 2968639985 @default.
• W2968639985 citedByCount "5" @default.
• W2968639985 countsByYear W29686399852019 @default.
• W2968639985 countsByYear W29686399852022 @default.
• W2968639985 countsByYear W29686399852023 @default.
• W2968639985 crossrefType "journal-article" @default.
• W2968639985 hasAuthorship W2968639985A5015300055 @default.
• W2968639985 hasAuthorship W2968639985A5025157783 @default.
• W2968639985 hasAuthorship W2968639985A5030629710 @default.
• W2968639985 hasAuthorship W2968639985A5032192154 @default.
• W2968639985 hasAuthorship W2968639985A5032786189 @default.
• W2968639985 hasAuthorship W2968639985A5058240991 @default.
• W2968639985 hasAuthorship W2968639985A5069959810 @default.
• W2968639985 hasAuthorship W2968639985A5073839386 @default.
• W2968639985 hasAuthorship W2968639985A5083725831 @default.
• W2968639985 hasBestOaLocation W29686399851 @default.
• W2968639985 hasConcept C181389837 @default.
• W2968639985 hasConcept C185592680 @default.
• W2968639985 hasConcept C202751555 @default.
• W2968639985 hasConcept C203014093 @default.
• W2968639985 hasConcept C207480886 @default.
• W2968639985 hasConcept C2777037608 @default.
• W2968639985 hasConcept C2779350572 @default.
• W2968639985 hasConcept C2780510475 @default.
• W2968639985 hasConcept C55493867 @default.
• W2968639985 hasConcept C57992300 @default.
• W2968639985 hasConcept C71924100 @default.
• W2968639985 hasConcept C98274493 @default.
• W2968639985 hasConceptScore W2968639985C181389837 @default.
• W2968639985 hasConceptScore W2968639985C185592680 @default.
• W2968639985 hasConceptScore W2968639985C202751555 @default.
• W2968639985 hasConceptScore W2968639985C203014093 @default.
• W2968639985 hasConceptScore W2968639985C207480886 @default.
• W2968639985 hasConceptScore W2968639985C2777037608 @default.
• W2968639985 hasConceptScore W2968639985C2779350572 @default.
• W2968639985 hasConceptScore W2968639985C2780510475 @default.
• W2968639985 hasConceptScore W2968639985C55493867 @default.
• W2968639985 hasConceptScore W2968639985C57992300 @default.
• W2968639985 hasConceptScore W2968639985C71924100 @default.
• W2968639985 hasConceptScore W2968639985C98274493 @default.
• W2968639985 hasIssue "9" @default.
• W2968639985 hasLocation W29686399851 @default.

• next