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- W2968644307 abstract "The sensor kinases MsmS and RdmS from the methanogenic archaeon Methanosarcina acetivorans are multidomain proteins containing a covalently linked heme cofactor. This cofactor is connected via a single cysteine residue in a GAF domain. Although both proteins were shown to display a redox-dependent control of the downstream kinase module, this property appears to be independent of the heme cofactor. We therefore envision an additional sensor role for the heme cofactor. In order to learn more about the heme binding pocket and its constitution, UV-vis spectroscopy in combination with site-directed mutagenesis was performed on the isolated heme-binding sGAF2 domain and the full-length protein. The data indicate a 6-coordinated heme with a proximal histidine ligand and a smaller ligand, likely a water molecule on the distal site. The latter is also thought to be the sensory site and is shown to easily undergo ligand exchange." @default.
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- W2968644307 date "2019-07-01" @default.
- W2968644307 modified "2023-09-27" @default.
- W2968644307 title "Spectroscopic characterization of the heme binding (GAF) domain of two sensor kinases from Methanosarcina acetivorans" @default.
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- W2968644307 doi "https://doi.org/10.1142/s1088424619500883" @default.
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