Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968650613> ?p ?o ?g. }
- W2968650613 endingPage "1658" @default.
- W2968650613 startingPage "1641" @default.
- W2968650613 abstract "GATA3 is a dual-zinc finger transcription factor that regulates gene expression in many developing tissues. In the kidney, GATA3 is essential for ureteric bud branching, and mice without it fail to develop kidneys. In humans, autosomal dominant GATA3 mutations can cause renal aplasia as part of the hypoparathyroidism, renal dysplasia, deafness (HDR) syndrome that includes mesangioproliferative GN. This suggests that GATA3 may have a previously unrecognized role in glomerular development or injury.To determine GATA3's role in glomerular development or injury, we assessed GATA3 expression in developing and mature kidneys from Gata3 heterozygous (+/-) knockout mice, as well as injured human and rodent kidneys.We show that GATA3 is expressed by FOXD1 lineage stromal progenitor cells, and a subset of these cells mature into mesangial cells (MCs) that continue to express GATA3 in adult kidneys. In mice, we uncover that GATA3 is essential for normal glomerular development, and mice with haploinsufficiency of Gata3 have too few MC precursors and glomerular abnormalities. Expression of GATA3 is maintained in MCs of adult kidneys and is markedly increased in rodent models of mesangioproliferative GN and in IgA nephropathy, suggesting that GATA3 plays a critical role in the maintenance of glomerular homeostasis.These results provide new insights on the role GATA3 plays in MC development and response to injury. It also shows that GATA3 may be a novel and robust nuclear marker for identifying MCs in tissue sections." @default.
- W2968650613 created "2019-08-22" @default.
- W2968650613 creator A5001027249 @default.
- W2968650613 creator A5010415549 @default.
- W2968650613 creator A5011631552 @default.
- W2968650613 creator A5048677837 @default.
- W2968650613 creator A5051791806 @default.
- W2968650613 creator A5054492137 @default.
- W2968650613 creator A5054550346 @default.
- W2968650613 creator A5056347519 @default.
- W2968650613 creator A5059102060 @default.
- W2968650613 creator A5065533886 @default.
- W2968650613 creator A5066049265 @default.
- W2968650613 creator A5076577191 @default.
- W2968650613 creator A5080589561 @default.
- W2968650613 creator A5081517268 @default.
- W2968650613 creator A5090465511 @default.
- W2968650613 creator A5090564688 @default.
- W2968650613 date "2019-08-12" @default.
- W2968650613 modified "2023-10-18" @default.
- W2968650613 title "A Novel Role for GATA3 in Mesangial Cells in Glomerular Development and Injury" @default.
- W2968650613 cites W1487926964 @default.
- W2968650613 cites W1556322054 @default.
- W2968650613 cites W1560771695 @default.
- W2968650613 cites W1561598641 @default.
- W2968650613 cites W1848816727 @default.
- W2968650613 cites W1971359363 @default.
- W2968650613 cites W1975214275 @default.
- W2968650613 cites W1976739900 @default.
- W2968650613 cites W1978271990 @default.
- W2968650613 cites W1983426462 @default.
- W2968650613 cites W1983752167 @default.
- W2968650613 cites W1988554428 @default.
- W2968650613 cites W1993563498 @default.
- W2968650613 cites W1994569436 @default.
- W2968650613 cites W1996735209 @default.
- W2968650613 cites W2001534689 @default.
- W2968650613 cites W2001928210 @default.
- W2968650613 cites W2011033373 @default.
- W2968650613 cites W2012161473 @default.
- W2968650613 cites W2015193920 @default.
- W2968650613 cites W2021017423 @default.
- W2968650613 cites W2031945829 @default.
- W2968650613 cites W2039309643 @default.
- W2968650613 cites W2040008547 @default.
- W2968650613 cites W2042784167 @default.
- W2968650613 cites W2057340599 @default.
- W2968650613 cites W2079386317 @default.
- W2968650613 cites W2094553248 @default.
- W2968650613 cites W2107664245 @default.
- W2968650613 cites W2111940985 @default.
- W2968650613 cites W2114008865 @default.
- W2968650613 cites W2127065370 @default.
- W2968650613 cites W2131583554 @default.
- W2968650613 cites W2137322577 @default.
- W2968650613 cites W2137571953 @default.
- W2968650613 cites W2138712142 @default.
- W2968650613 cites W2139442812 @default.
- W2968650613 cites W2149582300 @default.
- W2968650613 cites W2152046643 @default.
- W2968650613 cites W2152329008 @default.
- W2968650613 cites W2157795344 @default.
- W2968650613 cites W2162649803 @default.
- W2968650613 cites W2162928850 @default.
- W2968650613 cites W2167589429 @default.
- W2968650613 cites W2258974454 @default.
- W2968650613 cites W2281053309 @default.
- W2968650613 cites W2471389624 @default.
- W2968650613 cites W2518654183 @default.
- W2968650613 cites W2585818961 @default.
- W2968650613 cites W2596294910 @default.
- W2968650613 cites W2602196428 @default.
- W2968650613 cites W2620166530 @default.
- W2968650613 cites W2670000028 @default.
- W2968650613 cites W2745104857 @default.
- W2968650613 cites W4294107304 @default.
- W2968650613 doi "https://doi.org/10.1681/asn.2018111143" @default.
- W2968650613 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6727249" @default.
- W2968650613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31405951" @default.
- W2968650613 hasPublicationYear "2019" @default.
- W2968650613 type Work @default.
- W2968650613 sameAs 2968650613 @default.
- W2968650613 citedByCount "27" @default.
- W2968650613 countsByYear W29686506132019 @default.
- W2968650613 countsByYear W29686506132020 @default.
- W2968650613 countsByYear W29686506132021 @default.
- W2968650613 countsByYear W29686506132022 @default.
- W2968650613 countsByYear W29686506132023 @default.
- W2968650613 crossrefType "journal-article" @default.
- W2968650613 hasAuthorship W2968650613A5001027249 @default.
- W2968650613 hasAuthorship W2968650613A5010415549 @default.
- W2968650613 hasAuthorship W2968650613A5011631552 @default.
- W2968650613 hasAuthorship W2968650613A5048677837 @default.
- W2968650613 hasAuthorship W2968650613A5051791806 @default.
- W2968650613 hasAuthorship W2968650613A5054492137 @default.
- W2968650613 hasAuthorship W2968650613A5054550346 @default.
- W2968650613 hasAuthorship W2968650613A5056347519 @default.
- W2968650613 hasAuthorship W2968650613A5059102060 @default.