Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968708487> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2968708487 abstract "Background: Transdermal delivery of meloxicam is advantageous than the oral route in the treatment of pain management. Objective: The goal of the present study is to formulate and evaluate meloxicam (MX) loaded nanosuspensions based gel for transdermal application. Methods: The formulation parameters were optimized using Box Behnken design (BBD) taking three independent variables and three responses. Formulations were evaluated for particle size (nm), polydispersity index (PDI), zeta potential (mV), ex vivo permeation, in vivo study, morphology, FTIR, skin irritation and, stability study. Optimized formulation having Poloxamer 188 (0.4 mg), PVP K30 (0.5 mg) and sonication time (60 min.) demonstrated smaller particle size (159.2 ± 3.5 nm), low PDI (0.120 ± 0.01) and higher zeta potential value (-29 ± 4mV). Results: In the ex vivo study, MX-NG showed a significant increase (p<0.05) in the flux (24.40 ± 2.6 μg/cm2/h) of meloxicam through the human cadaver skin as compared to other formulations. In the in- vivo study, MX-NG showed a significant (p<0.05) increase in anti-inflammatory activity as compared to marketed gel. Conclusion: Thus, it is concluded that the developed meloxicam loaded nanosuspensions based gel showed maximum therapeutic effects in rats." @default.
- W2968708487 created "2019-08-22" @default.
- W2968708487 creator A5009368035 @default.
- W2968708487 creator A5021945470 @default.
- W2968708487 creator A5060710188 @default.
- W2968708487 creator A5084090208 @default.
- W2968708487 date "2020-11-30" @default.
- W2968708487 modified "2023-09-27" @default.
- W2968708487 title "Dermal Delivery of Meloxicam Nanosuspensions based Gel: Optimization with Box Behnken Design Experiment Approach: Ex Vivo and In Vivo Study" @default.
- W2968708487 doi "https://doi.org/10.2174/2210681209666190809103155" @default.
- W2968708487 hasPublicationYear "2020" @default.
- W2968708487 type Work @default.
- W2968708487 sameAs 2968708487 @default.
- W2968708487 citedByCount "0" @default.
- W2968708487 crossrefType "journal-article" @default.
- W2968708487 hasAuthorship W2968708487A5009368035 @default.
- W2968708487 hasAuthorship W2968708487A5021945470 @default.
- W2968708487 hasAuthorship W2968708487A5060710188 @default.
- W2968708487 hasAuthorship W2968708487A5084090208 @default.
- W2968708487 hasConcept C101335993 @default.
- W2968708487 hasConcept C104628117 @default.
- W2968708487 hasConcept C11432220 @default.
- W2968708487 hasConcept C136229726 @default.
- W2968708487 hasConcept C147789679 @default.
- W2968708487 hasConcept C150077022 @default.
- W2968708487 hasConcept C150903083 @default.
- W2968708487 hasConcept C155672457 @default.
- W2968708487 hasConcept C15920480 @default.
- W2968708487 hasConcept C159985019 @default.
- W2968708487 hasConcept C170295934 @default.
- W2968708487 hasConcept C171250308 @default.
- W2968708487 hasConcept C185592680 @default.
- W2968708487 hasConcept C187530423 @default.
- W2968708487 hasConcept C188027245 @default.
- W2968708487 hasConcept C192562407 @default.
- W2968708487 hasConcept C205679159 @default.
- W2968708487 hasConcept C207001950 @default.
- W2968708487 hasConcept C26291073 @default.
- W2968708487 hasConcept C2779751750 @default.
- W2968708487 hasConcept C2780306666 @default.
- W2968708487 hasConcept C41625074 @default.
- W2968708487 hasConcept C43617362 @default.
- W2968708487 hasConcept C50670333 @default.
- W2968708487 hasConcept C521977710 @default.
- W2968708487 hasConcept C55493867 @default.
- W2968708487 hasConcept C71924100 @default.
- W2968708487 hasConcept C86181022 @default.
- W2968708487 hasConcept C86803240 @default.
- W2968708487 hasConcept C98274493 @default.
- W2968708487 hasConceptScore W2968708487C101335993 @default.
- W2968708487 hasConceptScore W2968708487C104628117 @default.
- W2968708487 hasConceptScore W2968708487C11432220 @default.
- W2968708487 hasConceptScore W2968708487C136229726 @default.
- W2968708487 hasConceptScore W2968708487C147789679 @default.
- W2968708487 hasConceptScore W2968708487C150077022 @default.
- W2968708487 hasConceptScore W2968708487C150903083 @default.
- W2968708487 hasConceptScore W2968708487C155672457 @default.
- W2968708487 hasConceptScore W2968708487C15920480 @default.
- W2968708487 hasConceptScore W2968708487C159985019 @default.
- W2968708487 hasConceptScore W2968708487C170295934 @default.
- W2968708487 hasConceptScore W2968708487C171250308 @default.
- W2968708487 hasConceptScore W2968708487C185592680 @default.
- W2968708487 hasConceptScore W2968708487C187530423 @default.
- W2968708487 hasConceptScore W2968708487C188027245 @default.
- W2968708487 hasConceptScore W2968708487C192562407 @default.
- W2968708487 hasConceptScore W2968708487C205679159 @default.
- W2968708487 hasConceptScore W2968708487C207001950 @default.
- W2968708487 hasConceptScore W2968708487C26291073 @default.
- W2968708487 hasConceptScore W2968708487C2779751750 @default.
- W2968708487 hasConceptScore W2968708487C2780306666 @default.
- W2968708487 hasConceptScore W2968708487C41625074 @default.
- W2968708487 hasConceptScore W2968708487C43617362 @default.
- W2968708487 hasConceptScore W2968708487C50670333 @default.
- W2968708487 hasConceptScore W2968708487C521977710 @default.
- W2968708487 hasConceptScore W2968708487C55493867 @default.
- W2968708487 hasConceptScore W2968708487C71924100 @default.
- W2968708487 hasConceptScore W2968708487C86181022 @default.
- W2968708487 hasConceptScore W2968708487C86803240 @default.
- W2968708487 hasConceptScore W2968708487C98274493 @default.
- W2968708487 hasLocation W29687084871 @default.
- W2968708487 hasOpenAccess W2968708487 @default.
- W2968708487 hasPrimaryLocation W29687084871 @default.
- W2968708487 hasRelatedWork W10403013 @default.
- W2968708487 hasRelatedWork W18910779 @default.
- W2968708487 hasRelatedWork W19358972 @default.
- W2968708487 hasRelatedWork W20226851 @default.
- W2968708487 hasRelatedWork W23461526 @default.
- W2968708487 hasRelatedWork W24158308 @default.
- W2968708487 hasRelatedWork W24701455 @default.
- W2968708487 hasRelatedWork W5605747 @default.
- W2968708487 hasRelatedWork W5717607 @default.
- W2968708487 hasRelatedWork W7001169 @default.
- W2968708487 isParatext "false" @default.
- W2968708487 isRetracted "false" @default.
- W2968708487 magId "2968708487" @default.
- W2968708487 workType "article" @default.