Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968709097> ?p ?o ?g. }
- W2968709097 abstract "Acute inflammation increases the risk of cardiac and cerebrovascular events, possibly related to alterations in the hemodynamic load. Wave reflection at the aorta and carotid provides insight into downstream vascular changes and hemodynamic load at the heart and brain. Acute inflammation has been suggested to reduce wave reflection via downstream vasodilation; however, this is not firmly established and has only been investigated at the aorta. We sought to explore the effect of acute inflammation on aortic and carotid hemodynamics in healthy, young adults. Pressure waveforms were collected via radial and carotid applanation tonometry in 23 adults (26 ± 4 years) before and 24 h after a typhoid vaccination. Waveforms were calibrated to brachial mean and diastolic pressure, and waveform separation analyses (WSA) were performed, yielding augmentation index, reflection index, time to reflection (Tr), forward (Pf) and reflected (Pb) wave magnitude, and pulse wave velocity. Arterial diameters and carotid stiffness were measured via ultrasonography. Acute inflammation reduced wave reflection at 24 h in both the aorta and carotid (P < 0.05) without changes in mean pressure. WSA did not reveal independent changes in Pf, Pb, or Tr (P > 0.05). Arterial stiffness did not change; however, brachial and carotid artery diameters increased. Acute inflammation reduces wave reflection in the aorta and carotid artery in young adults, potentially due to downstream/peripheral vasodilation. Reduced aortic wave reflection did not disturb the cardiac workload; however, reductions in carotid wave reflection may render the brain vulnerable to pulsatile hemodynamics. These findings may have implications for cardiac and cerebrovascular risk during acute inflammation." @default.
- W2968709097 created "2019-08-22" @default.
- W2968709097 creator A5017059733 @default.
- W2968709097 creator A5018032598 @default.
- W2968709097 creator A5061287540 @default.
- W2968709097 creator A5083215165 @default.
- W2968709097 date "2019-08-01" @default.
- W2968709097 modified "2023-10-14" @default.
- W2968709097 title "Acute systemic inflammation reduces both carotid and aortic wave reflection in healthy adults" @default.
- W2968709097 cites W1537679123 @default.
- W2968709097 cites W1586081684 @default.
- W2968709097 cites W1612438936 @default.
- W2968709097 cites W1971940683 @default.
- W2968709097 cites W1994103973 @default.
- W2968709097 cites W2011032385 @default.
- W2968709097 cites W2012030177 @default.
- W2968709097 cites W2018074094 @default.
- W2968709097 cites W2020496288 @default.
- W2968709097 cites W2059734836 @default.
- W2968709097 cites W2059969387 @default.
- W2968709097 cites W2066442598 @default.
- W2968709097 cites W2067833505 @default.
- W2968709097 cites W2072376419 @default.
- W2968709097 cites W2073061983 @default.
- W2968709097 cites W2096998744 @default.
- W2968709097 cites W2124313450 @default.
- W2968709097 cites W2125903736 @default.
- W2968709097 cites W2133098776 @default.
- W2968709097 cites W2135326848 @default.
- W2968709097 cites W2138209376 @default.
- W2968709097 cites W2140942338 @default.
- W2968709097 cites W2144624688 @default.
- W2968709097 cites W2144873061 @default.
- W2968709097 cites W2149177924 @default.
- W2968709097 cites W2151910685 @default.
- W2968709097 cites W2156374752 @default.
- W2968709097 cites W2157053766 @default.
- W2968709097 cites W2320905681 @default.
- W2968709097 cites W2531006139 @default.
- W2968709097 cites W2535138218 @default.
- W2968709097 cites W2559432673 @default.
- W2968709097 cites W2559649367 @default.
- W2968709097 cites W2623111196 @default.
- W2968709097 cites W2790427241 @default.
- W2968709097 cites W2801008596 @default.
- W2968709097 cites W2811235177 @default.
- W2968709097 cites W2898289614 @default.
- W2968709097 cites W2968709097 @default.
- W2968709097 cites W3016405830 @default.
- W2968709097 doi "https://doi.org/10.14814/phy2.14203" @default.
- W2968709097 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6689683" @default.
- W2968709097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31402635" @default.
- W2968709097 hasPublicationYear "2019" @default.
- W2968709097 type Work @default.
- W2968709097 sameAs 2968709097 @default.
- W2968709097 citedByCount "4" @default.
- W2968709097 countsByYear W29687090972021 @default.
- W2968709097 countsByYear W29687090972023 @default.
- W2968709097 crossrefType "journal-article" @default.
- W2968709097 hasAuthorship W2968709097A5017059733 @default.
- W2968709097 hasAuthorship W2968709097A5018032598 @default.
- W2968709097 hasAuthorship W2968709097A5061287540 @default.
- W2968709097 hasAuthorship W2968709097A5083215165 @default.
- W2968709097 hasBestOaLocation W29687090971 @default.
- W2968709097 hasConcept C126322002 @default.
- W2968709097 hasConcept C164705383 @default.
- W2968709097 hasConcept C17140001 @default.
- W2968709097 hasConcept C178853913 @default.
- W2968709097 hasConcept C2775850156 @default.
- W2968709097 hasConcept C2778319312 @default.
- W2968709097 hasConcept C2779980429 @default.
- W2968709097 hasConcept C2781064879 @default.
- W2968709097 hasConcept C2987047532 @default.
- W2968709097 hasConcept C71924100 @default.
- W2968709097 hasConcept C79191276 @default.
- W2968709097 hasConcept C84393581 @default.
- W2968709097 hasConceptScore W2968709097C126322002 @default.
- W2968709097 hasConceptScore W2968709097C164705383 @default.
- W2968709097 hasConceptScore W2968709097C17140001 @default.
- W2968709097 hasConceptScore W2968709097C178853913 @default.
- W2968709097 hasConceptScore W2968709097C2775850156 @default.
- W2968709097 hasConceptScore W2968709097C2778319312 @default.
- W2968709097 hasConceptScore W2968709097C2779980429 @default.
- W2968709097 hasConceptScore W2968709097C2781064879 @default.
- W2968709097 hasConceptScore W2968709097C2987047532 @default.
- W2968709097 hasConceptScore W2968709097C71924100 @default.
- W2968709097 hasConceptScore W2968709097C79191276 @default.
- W2968709097 hasConceptScore W2968709097C84393581 @default.
- W2968709097 hasIssue "15" @default.
- W2968709097 hasLocation W29687090971 @default.
- W2968709097 hasLocation W29687090972 @default.
- W2968709097 hasLocation W29687090973 @default.
- W2968709097 hasLocation W29687090974 @default.
- W2968709097 hasOpenAccess W2968709097 @default.
- W2968709097 hasPrimaryLocation W29687090971 @default.
- W2968709097 hasRelatedWork W1988185378 @default.
- W2968709097 hasRelatedWork W2011999423 @default.
- W2968709097 hasRelatedWork W2064080571 @default.
- W2968709097 hasRelatedWork W2746488270 @default.
- W2968709097 hasRelatedWork W2802745373 @default.