Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968730900> ?p ?o ?g. }
- W2968730900 endingPage "924" @default.
- W2968730900 startingPage "917" @default.
- W2968730900 abstract "We describe a synthetic genetic circuit for controlling asymmetric cell division in Escherichia coli in which a progenitor cell creates a differentiated daughter cell while retaining its original phenotype. Specifically, we engineered an inducible system that can bind and segregate plasmid DNA to a single position in the cell. Upon cell division, colocalized plasmids are kept by one and only one of the daughter cells. The other daughter cell receives no plasmid DNA and is irreversibly differentiated from its sibling. In this way, we achieved asymmetric cell division through asymmetric plasmid partitioning. We then used this system to achieve physical separation of genetically distinct cells by tying motility to differentiation. Finally, we characterized an orthogonal inducible circuit that enables the simultaneous asymmetric partitioning of two plasmid species, resulting in cells that have four distinct differentiated states. These results point the way toward the engineering of multicellular systems from prokaryotic hosts." @default.
- W2968730900 created "2019-08-22" @default.
- W2968730900 creator A5009034042 @default.
- W2968730900 creator A5016582420 @default.
- W2968730900 creator A5020448227 @default.
- W2968730900 creator A5053287366 @default.
- W2968730900 creator A5059896756 @default.
- W2968730900 creator A5060205932 @default.
- W2968730900 date "2019-08-12" @default.
- W2968730900 modified "2023-10-09" @default.
- W2968730900 title "A synthetic system for asymmetric cell division in Escherichia coli" @default.
- W2968730900 cites W1532814292 @default.
- W2968730900 cites W1821797507 @default.
- W2968730900 cites W1963513493 @default.
- W2968730900 cites W1965233744 @default.
- W2968730900 cites W1975304761 @default.
- W2968730900 cites W1977624796 @default.
- W2968730900 cites W1977685098 @default.
- W2968730900 cites W1999679140 @default.
- W2968730900 cites W1999732677 @default.
- W2968730900 cites W2008897847 @default.
- W2968730900 cites W2013330518 @default.
- W2968730900 cites W2017862866 @default.
- W2968730900 cites W2018435536 @default.
- W2968730900 cites W2020206842 @default.
- W2968730900 cites W2023732922 @default.
- W2968730900 cites W2026697234 @default.
- W2968730900 cites W2028622989 @default.
- W2968730900 cites W2031688735 @default.
- W2968730900 cites W2032183472 @default.
- W2968730900 cites W2041333999 @default.
- W2968730900 cites W2054665436 @default.
- W2968730900 cites W2055751656 @default.
- W2968730900 cites W2060603511 @default.
- W2968730900 cites W2071523283 @default.
- W2968730900 cites W2082398508 @default.
- W2968730900 cites W2092533253 @default.
- W2968730900 cites W2099082448 @default.
- W2968730900 cites W2111759547 @default.
- W2968730900 cites W2113979580 @default.
- W2968730900 cites W2114228460 @default.
- W2968730900 cites W2121987905 @default.
- W2968730900 cites W2123097315 @default.
- W2968730900 cites W2125987139 @default.
- W2968730900 cites W2132828256 @default.
- W2968730900 cites W2134759932 @default.
- W2968730900 cites W2134915935 @default.
- W2968730900 cites W2138835511 @default.
- W2968730900 cites W2141564052 @default.
- W2968730900 cites W2146709745 @default.
- W2968730900 cites W2160347838 @default.
- W2968730900 cites W2160803964 @default.
- W2968730900 cites W2162642438 @default.
- W2968730900 cites W2166744717 @default.
- W2968730900 cites W2416471421 @default.
- W2968730900 cites W2513592175 @default.
- W2968730900 cites W2541391822 @default.
- W2968730900 cites W2726013144 @default.
- W2968730900 cites W2734417326 @default.
- W2968730900 cites W2901363692 @default.
- W2968730900 cites W2950815161 @default.
- W2968730900 doi "https://doi.org/10.1038/s41589-019-0339-x" @default.
- W2968730900 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6702073" @default.
- W2968730900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31406375" @default.
- W2968730900 hasPublicationYear "2019" @default.
- W2968730900 type Work @default.
- W2968730900 sameAs 2968730900 @default.
- W2968730900 citedByCount "25" @default.
- W2968730900 countsByYear W29687309002019 @default.
- W2968730900 countsByYear W29687309002020 @default.
- W2968730900 countsByYear W29687309002021 @default.
- W2968730900 countsByYear W29687309002022 @default.
- W2968730900 countsByYear W29687309002023 @default.
- W2968730900 crossrefType "journal-article" @default.
- W2968730900 hasAuthorship W2968730900A5009034042 @default.
- W2968730900 hasAuthorship W2968730900A5016582420 @default.
- W2968730900 hasAuthorship W2968730900A5020448227 @default.
- W2968730900 hasAuthorship W2968730900A5053287366 @default.
- W2968730900 hasAuthorship W2968730900A5059896756 @default.
- W2968730900 hasAuthorship W2968730900A5060205932 @default.
- W2968730900 hasBestOaLocation W29687309002 @default.
- W2968730900 hasConcept C104317684 @default.
- W2968730900 hasConcept C1491633281 @default.
- W2968730900 hasConcept C201750760 @default.
- W2968730900 hasConcept C22744801 @default.
- W2968730900 hasConcept C2778977658 @default.
- W2968730900 hasConcept C28328180 @default.
- W2968730900 hasConcept C54355233 @default.
- W2968730900 hasConcept C547475151 @default.
- W2968730900 hasConcept C552990157 @default.
- W2968730900 hasConcept C74318829 @default.
- W2968730900 hasConcept C85813293 @default.
- W2968730900 hasConcept C86803240 @default.
- W2968730900 hasConcept C95444343 @default.
- W2968730900 hasConceptScore W2968730900C104317684 @default.
- W2968730900 hasConceptScore W2968730900C1491633281 @default.
- W2968730900 hasConceptScore W2968730900C201750760 @default.
- W2968730900 hasConceptScore W2968730900C22744801 @default.