FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968754995> ?p ?o ?g. }

• W2968754995 endingPage "110063" @default.
• W2968754995 startingPage "110063" @default.
• W2968754995 abstract "Artificial dermal scaffolds, which are made of natural or synthetic materials, can improve new blood vessel formation, cell migration and cell proliferation after being implanted into wounds, and they degrade slowly, playing an important role in dermal reconstruction and scar inhibition, finally achieving the goal of wound healing and functional reconstruction. Although these scaffolds have been widely used in clinical applications, biomaterial-associated infection is a deficiency or even a life-threatening problem that must be addressed, as it greatly affects the survival of the scaffolds. The gallium ion (Ga3+) is a novel metallic antimicrobial whose broad-spectrum antimicrobial properties against most bacteria encountered in burn wound infections have been confirmed, and it has been proposed as a promising candidate to prevent implant-associated infections. In this study, a gallium-loaded antimicrobial artificial dermal scaffold was successfully prepared by gallium ions and a collagen solution. The characterization results showed a porous structure with pore sizes ranging from 50 to 150 μm and a large porosity value of 97.4%. The enzymatic degradation rate in vitro was 19 and 28% after 12 and 24 h, respectively. In vitro antimicrobial testing revealed that the 1 h antibacterial rate against Staphylococcus aureus and Pseudomonas aeruginosa was close to 90%, which indicated its great antimicrobial activity. The results of the cytological evaluation showed slight effect on cell proliferation, with a relative growth rate (RGR) value of 80% and great cytocompatibility with cultured cells according to laser scanning confocal microscopy (LSCM) and scanning electron microscope (SEM). Furthermore, the successful prevention of wound infections in SD rats was confirmed with an in vivo antimicrobial evaluation, and the artificial dermal scaffolds also demonstrated great biocompatibility. This gallium-loaded antimicrobial artificial dermal scaffold exerted excellent antimicrobial activity and great biosafety, warranting further research for future clinical applications." @default.
• W2968754995 created "2019-08-22" @default.
• W2968754995 creator A5007920592 @default.
• W2968754995 creator A5034654778 @default.
• W2968754995 creator A5046548706 @default.
• W2968754995 creator A5059256591 @default.
• W2968754995 creator A5075076354 @default.
• W2968754995 creator A5088439519 @default.
• W2968754995 date "2019-12-01" @default.
• W2968754995 modified "2023-10-12" @default.
• W2968754995 title "Preparation and characterization of a gallium-loaded antimicrobial artificial dermal scaffold" @default.
• W2968754995 cites W1968822465 @default.
• W2968754995 cites W1968831463 @default.
• W2968754995 cites W1972634870 @default.
• W2968754995 cites W1986278301 @default.
• W2968754995 cites W1995714414 @default.
• W2968754995 cites W1996227079 @default.
• W2968754995 cites W1999503973 @default.
• W2968754995 cites W2021406571 @default.
• W2968754995 cites W2028609922 @default.
• W2968754995 cites W2046785459 @default.
• W2968754995 cites W2052564398 @default.
• W2968754995 cites W2076921592 @default.
• W2968754995 cites W2079028650 @default.
• W2968754995 cites W2086208659 @default.
• W2968754995 cites W2090370229 @default.
• W2968754995 cites W2092717233 @default.
• W2968754995 cites W2098976774 @default.
• W2968754995 cites W2105698469 @default.
• W2968754995 cites W2137416120 @default.
• W2968754995 cites W2156640964 @default.
• W2968754995 cites W2162742345 @default.
• W2968754995 cites W2165906489 @default.
• W2968754995 cites W2179800251 @default.
• W2968754995 cites W2288616517 @default.
• W2968754995 cites W2338132901 @default.
• W2968754995 cites W2411435579 @default.
• W2968754995 cites W2415505959 @default.
• W2968754995 cites W2529396280 @default.
• W2968754995 cites W2550009735 @default.
• W2968754995 cites W2734329881 @default.
• W2968754995 cites W2735588417 @default.
• W2968754995 cites W2767659367 @default.
• W2968754995 cites W2793818596 @default.
• W2968754995 cites W2801706183 @default.
• W2968754995 cites W4233068027 @default.
• W2968754995 cites W4361804755 @default.
• W2968754995 cites W620425633 @default.
• W2968754995 doi "https://doi.org/10.1016/j.msec.2019.110063" @default.
• W2968754995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31546412" @default.
• W2968754995 hasPublicationYear "2019" @default.
• W2968754995 type Work @default.
• W2968754995 sameAs 2968754995 @default.
• W2968754995 citedByCount "19" @default.
• W2968754995 countsByYear W29687549952020 @default.
• W2968754995 countsByYear W29687549952021 @default.
• W2968754995 countsByYear W29687549952022 @default.
• W2968754995 countsByYear W29687549952023 @default.
• W2968754995 crossrefType "journal-article" @default.
• W2968754995 hasAuthorship W2968754995A5007920592 @default.
• W2968754995 hasAuthorship W2968754995A5034654778 @default.
• W2968754995 hasAuthorship W2968754995A5046548706 @default.
• W2968754995 hasAuthorship W2968754995A5059256591 @default.
• W2968754995 hasAuthorship W2968754995A5075076354 @default.
• W2968754995 hasAuthorship W2968754995A5088439519 @default.
• W2968754995 hasConcept C12554922 @default.
• W2968754995 hasConcept C136229726 @default.
• W2968754995 hasConcept C141071460 @default.
• W2968754995 hasConcept C159985019 @default.
• W2968754995 hasConcept C171250308 @default.
• W2968754995 hasConcept C185592680 @default.
• W2968754995 hasConcept C191897082 @default.
• W2968754995 hasConcept C192562407 @default.
• W2968754995 hasConcept C202751555 @default.
• W2968754995 hasConcept C26771246 @default.
• W2968754995 hasConcept C2777637488 @default.
• W2968754995 hasConcept C2778414984 @default.
• W2968754995 hasConcept C2779489039 @default.
• W2968754995 hasConcept C2780269544 @default.
• W2968754995 hasConcept C4937899 @default.
• W2968754995 hasConcept C523546767 @default.
• W2968754995 hasConcept C54355233 @default.
• W2968754995 hasConcept C550372918 @default.
• W2968754995 hasConcept C55493867 @default.
• W2968754995 hasConcept C71924100 @default.
• W2968754995 hasConcept C86803240 @default.
• W2968754995 hasConcept C89423630 @default.
• W2968754995 hasConcept C89429830 @default.
• W2968754995 hasConceptScore W2968754995C12554922 @default.
• W2968754995 hasConceptScore W2968754995C136229726 @default.
• W2968754995 hasConceptScore W2968754995C141071460 @default.
• W2968754995 hasConceptScore W2968754995C159985019 @default.
• W2968754995 hasConceptScore W2968754995C171250308 @default.
• W2968754995 hasConceptScore W2968754995C185592680 @default.
• W2968754995 hasConceptScore W2968754995C191897082 @default.
• W2968754995 hasConceptScore W2968754995C192562407 @default.
• W2968754995 hasConceptScore W2968754995C202751555 @default.
• W2968754995 hasConceptScore W2968754995C26771246 @default.

• next