Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968761716> ?p ?o ?g. }
- W2968761716 endingPage "7059" @default.
- W2968761716 startingPage "7046" @default.
- W2968761716 abstract "Deleted in Liver Cancer 1 (DLC1) is a tumor suppressor gene deleted in many cancers, including angiosarcoma, an aggressive malignancy of endothelial cell derivation. DLC1-deficiency in primary endothelial cells causes the loss of cell contact inhibition of growth through incompletely defined mechanisms. We report that DLC1 is a regulator of YAP, a transcriptional coactivator of proliferation-promoting and tumor-promoting genes; when confluent, active/nuclear YAP was significantly more abundant in DLC1-deficient endothelial cells compared with control cells. We also found that YAP is a required effector of the loss of cell contact inhibition of growth manifested by DLC1-deficient endothelial cells, as the silencing of YAP prevents this loss. Consistently, human angiosarcomas specimens contained a significantly greater proportion of DLC1− tumor cells with nuclear YAP compared with the DLC1+ normal cells in the adjacent tissue. Verteporfin, an inhibitor of YAP, significantly reduced angiosarcoma growth in mice. These results identify YAP as a previously unrecognized effector of DLC1 deficiency-associated loss of cell contact growth inhibition in endothelial cells and a potential therapeutic target in angiosarcoma." @default.
- W2968761716 created "2019-08-22" @default.
- W2968761716 creator A5004035173 @default.
- W2968761716 creator A5004104096 @default.
- W2968761716 creator A5005685966 @default.
- W2968761716 creator A5023533946 @default.
- W2968761716 creator A5035910616 @default.
- W2968761716 creator A5053231013 @default.
- W2968761716 creator A5065529659 @default.
- W2968761716 creator A5086620768 @default.
- W2968761716 date "2019-08-13" @default.
- W2968761716 modified "2023-10-14" @default.
- W2968761716 title "DLC1 deficiency and YAP signaling drive endothelial cell contact inhibition of growth and tumorigenesis" @default.
- W2968761716 cites W1539804860 @default.
- W2968761716 cites W1948593887 @default.
- W2968761716 cites W1955285242 @default.
- W2968761716 cites W1968776596 @default.
- W2968761716 cites W1970282054 @default.
- W2968761716 cites W1976323469 @default.
- W2968761716 cites W1980243795 @default.
- W2968761716 cites W1983035953 @default.
- W2968761716 cites W1995160678 @default.
- W2968761716 cites W1997335773 @default.
- W2968761716 cites W2002235642 @default.
- W2968761716 cites W2004480757 @default.
- W2968761716 cites W2012726972 @default.
- W2968761716 cites W2013316743 @default.
- W2968761716 cites W2027150010 @default.
- W2968761716 cites W2028194573 @default.
- W2968761716 cites W2033360354 @default.
- W2968761716 cites W2034269086 @default.
- W2968761716 cites W2037739086 @default.
- W2968761716 cites W2041299023 @default.
- W2968761716 cites W2043761739 @default.
- W2968761716 cites W2048410884 @default.
- W2968761716 cites W2049360086 @default.
- W2968761716 cites W2070460007 @default.
- W2968761716 cites W2071918743 @default.
- W2968761716 cites W2072304718 @default.
- W2968761716 cites W2078273305 @default.
- W2968761716 cites W2078429643 @default.
- W2968761716 cites W2085039090 @default.
- W2968761716 cites W2092622990 @default.
- W2968761716 cites W2095785781 @default.
- W2968761716 cites W2100641053 @default.
- W2968761716 cites W2105356859 @default.
- W2968761716 cites W2118611175 @default.
- W2968761716 cites W2120022879 @default.
- W2968761716 cites W2130086658 @default.
- W2968761716 cites W2141595533 @default.
- W2968761716 cites W2142588638 @default.
- W2968761716 cites W2148056172 @default.
- W2968761716 cites W2150002666 @default.
- W2968761716 cites W2159038842 @default.
- W2968761716 cites W2159376228 @default.
- W2968761716 cites W2167978765 @default.
- W2968761716 cites W2168717243 @default.
- W2968761716 cites W2171501785 @default.
- W2968761716 cites W2198052523 @default.
- W2968761716 cites W2266087322 @default.
- W2968761716 cites W2317655219 @default.
- W2968761716 cites W2347042877 @default.
- W2968761716 cites W2606495925 @default.
- W2968761716 cites W26093464 @default.
- W2968761716 cites W2735363547 @default.
- W2968761716 cites W2743161371 @default.
- W2968761716 cites W2749998272 @default.
- W2968761716 cites W2771792762 @default.
- W2968761716 cites W2773071087 @default.
- W2968761716 cites W2773364621 @default.
- W2968761716 cites W2775036186 @default.
- W2968761716 cites W2884435515 @default.
- W2968761716 cites W2960800806 @default.
- W2968761716 doi "https://doi.org/10.1038/s41388-019-0944-x" @default.
- W2968761716 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8276116" @default.
- W2968761716 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31409902" @default.
- W2968761716 hasPublicationYear "2019" @default.
- W2968761716 type Work @default.
- W2968761716 sameAs 2968761716 @default.
- W2968761716 citedByCount "10" @default.
- W2968761716 countsByYear W29687617162019 @default.
- W2968761716 countsByYear W29687617162020 @default.
- W2968761716 countsByYear W29687617162021 @default.
- W2968761716 countsByYear W29687617162022 @default.
- W2968761716 countsByYear W29687617162023 @default.
- W2968761716 crossrefType "journal-article" @default.
- W2968761716 hasAuthorship W2968761716A5004035173 @default.
- W2968761716 hasAuthorship W2968761716A5004104096 @default.
- W2968761716 hasAuthorship W2968761716A5005685966 @default.
- W2968761716 hasAuthorship W2968761716A5023533946 @default.
- W2968761716 hasAuthorship W2968761716A5035910616 @default.
- W2968761716 hasAuthorship W2968761716A5053231013 @default.
- W2968761716 hasAuthorship W2968761716A5065529659 @default.
- W2968761716 hasAuthorship W2968761716A5086620768 @default.
- W2968761716 hasBestOaLocation W29687617162 @default.
- W2968761716 hasConcept C121608353 @default.
- W2968761716 hasConcept C2778264664 @default.
- W2968761716 hasConcept C502942594 @default.