Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968790862> ?p ?o ?g. }
- W2968790862 endingPage "9684" @default.
- W2968790862 startingPage "9666" @default.
- W2968790862 abstract "Abstract Break induced replication (BIR) is a double strand break repair pathway that can promote genetic instabilities similar to those observed in cancer. Instead of a replication fork, BIR is driven by a migration bubble where asynchronous synthesis between leading and lagging strands leads to accumulation of single-stranded DNA (ssDNA) that promotes mutation. However, the details of the mechanism of mutagenesis, including the identity of the participating proteins, remain unknown. Using yeast as a model, we demonstrate that mutagenic ssDNA is formed at multiple positions along the BIR track and that Pol ζ is responsible for the majority of both spontaneous and damage-induced base substitutions during BIR. We also report that BIR creates a potent substrate for APOBEC3A (A3A) cytidine deaminase that can promote formation of mutation clusters along the entire track of BIR. Finally, we demonstrate that uracil glycosylase initiates the bypass of DNA damage induced by A3A in the context of BIR without formation of base substitutions, but instead this pathway frequently leads to chromosomal rearrangements. Together, the expression of A3A during BIR in yeast recapitulates the main features of APOBEC-induced kataegis in human cancers, suggesting that BIR might represent an important source of these hyper-mutagenic events." @default.
- W2968790862 created "2019-08-22" @default.
- W2968790862 creator A5012890881 @default.
- W2968790862 creator A5027609890 @default.
- W2968790862 creator A5033069001 @default.
- W2968790862 creator A5045510214 @default.
- W2968790862 creator A5048379856 @default.
- W2968790862 creator A5070502223 @default.
- W2968790862 creator A5090151610 @default.
- W2968790862 date "2019-08-08" @default.
- W2968790862 modified "2023-09-25" @default.
- W2968790862 title "Repair of base damage within break-induced replication intermediates promotes kataegis associated with chromosome rearrangements" @default.
- W2968790862 cites W1495608698 @default.
- W2968790862 cites W1557327055 @default.
- W2968790862 cites W1606049883 @default.
- W2968790862 cites W1792154290 @default.
- W2968790862 cites W1842792112 @default.
- W2968790862 cites W1863677123 @default.
- W2968790862 cites W1938041103 @default.
- W2968790862 cites W1946364834 @default.
- W2968790862 cites W1964831588 @default.
- W2968790862 cites W1968493165 @default.
- W2968790862 cites W1972984145 @default.
- W2968790862 cites W1984236815 @default.
- W2968790862 cites W1990828107 @default.
- W2968790862 cites W1991405085 @default.
- W2968790862 cites W2003236929 @default.
- W2968790862 cites W2003665515 @default.
- W2968790862 cites W2008255210 @default.
- W2968790862 cites W2011417152 @default.
- W2968790862 cites W2012838063 @default.
- W2968790862 cites W2022148699 @default.
- W2968790862 cites W2023218302 @default.
- W2968790862 cites W2042854528 @default.
- W2968790862 cites W2044563319 @default.
- W2968790862 cites W2050852487 @default.
- W2968790862 cites W2054560592 @default.
- W2968790862 cites W2059885034 @default.
- W2968790862 cites W2060822289 @default.
- W2968790862 cites W2063275754 @default.
- W2968790862 cites W2064855999 @default.
- W2968790862 cites W2067573570 @default.
- W2968790862 cites W2075478564 @default.
- W2968790862 cites W2077008254 @default.
- W2968790862 cites W2077570881 @default.
- W2968790862 cites W2077921362 @default.
- W2968790862 cites W2086333179 @default.
- W2968790862 cites W2094773814 @default.
- W2968790862 cites W2100057937 @default.
- W2968790862 cites W2109991075 @default.
- W2968790862 cites W2115998813 @default.
- W2968790862 cites W2118064322 @default.
- W2968790862 cites W2118393957 @default.
- W2968790862 cites W2127657018 @default.
- W2968790862 cites W2139831318 @default.
- W2968790862 cites W2144839130 @default.
- W2968790862 cites W2152061559 @default.
- W2968790862 cites W2156466607 @default.
- W2968790862 cites W2165630230 @default.
- W2968790862 cites W2167926463 @default.
- W2968790862 cites W2183570771 @default.
- W2968790862 cites W2204392137 @default.
- W2968790862 cites W2253310320 @default.
- W2968790862 cites W2320129379 @default.
- W2968790862 cites W2339705229 @default.
- W2968790862 cites W2514163422 @default.
- W2968790862 cites W2532734448 @default.
- W2968790862 cites W2542991120 @default.
- W2968790862 cites W2561547057 @default.
- W2968790862 cites W2592429281 @default.
- W2968790862 cites W2601286467 @default.
- W2968790862 cites W2607210226 @default.
- W2968790862 cites W2607341326 @default.
- W2968790862 cites W2783043796 @default.
- W2968790862 cites W2788084906 @default.
- W2968790862 cites W2800503833 @default.
- W2968790862 cites W61650054 @default.
- W2968790862 doi "https://doi.org/10.1093/nar/gkz651" @default.
- W2968790862 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6765108" @default.
- W2968790862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31392335" @default.
- W2968790862 hasPublicationYear "2019" @default.
- W2968790862 type Work @default.
- W2968790862 sameAs 2968790862 @default.
- W2968790862 citedByCount "24" @default.
- W2968790862 countsByYear W29687908622020 @default.
- W2968790862 countsByYear W29687908622021 @default.
- W2968790862 countsByYear W29687908622022 @default.
- W2968790862 countsByYear W29687908622023 @default.
- W2968790862 crossrefType "journal-article" @default.
- W2968790862 hasAuthorship W2968790862A5012890881 @default.
- W2968790862 hasAuthorship W2968790862A5027609890 @default.
- W2968790862 hasAuthorship W2968790862A5033069001 @default.
- W2968790862 hasAuthorship W2968790862A5045510214 @default.
- W2968790862 hasAuthorship W2968790862A5048379856 @default.
- W2968790862 hasAuthorship W2968790862A5070502223 @default.
- W2968790862 hasAuthorship W2968790862A5090151610 @default.
- W2968790862 hasBestOaLocation W29687908621 @default.
- W2968790862 hasConcept C104317684 @default.