FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968794930> ?p ?o ?g. }

• W2968794930 endingPage "408" @default.
• W2968794930 startingPage "408" @default.
• W2968794930 abstract "Choline kinase α1 (ChoKα1) has become an excellent antitumor target. Among all the inhibitors synthetized, the new compound Ff35 shows an excellent capacity to inhibit ChoKα1 activity. However, soluble Ff35 is also capable of inhibiting choline uptake, making the inhibitor not selective for ChoKα1. In this study, we designed a new protocol with the aim of disentangling whether the Ff35 biological action is due to the inhibition of the enzyme and/or to the choline uptake. Moreover, we offer an alternative to avoid the inhibition of choline uptake caused by Ff35, since the coupling of Ff35 to novel biomimetic magnetic nanoparticles (BMNPs) allows it to enter the cell through endocytosis without interacting with the choline transporter. This opens the possibility of a clinical use of Ff35. Our results indicate that Ff35-BMNPs nanoassemblies increase the selectivity of Ff35 and have an antiproliferative effect. Also, we demonstrate the effectiveness of the tandem Ff35-BMNPs and hyperthermia." @default.
• W2968794930 created "2019-08-22" @default.
• W2968794930 creator A5002952053 @default.
• W2968794930 creator A5006370304 @default.
• W2968794930 creator A5008212945 @default.
• W2968794930 creator A5018486980 @default.
• W2968794930 creator A5039994623 @default.
• W2968794930 creator A5041304639 @default.
• W2968794930 creator A5063699642 @default.
• W2968794930 creator A5072312871 @default.
• W2968794930 creator A5082312617 @default.
• W2968794930 creator A5083770622 @default.
• W2968794930 creator A5088496504 @default.
• W2968794930 date "2019-08-12" @default.
• W2968794930 modified "2023-10-14" @default.
• W2968794930 title "Biomimetic Magnetic Nanocarriers Drive Choline Kinase Alpha Inhibitor inside Cancer Cells for Combined Chemo-Hyperthermia Therapy" @default.
• W2968794930 cites W1541912458 @default.
• W2968794930 cites W1966458002 @default.
• W2968794930 cites W1968671216 @default.
• W2968794930 cites W1995138175 @default.
• W2968794930 cites W1996221314 @default.
• W2968794930 cites W2002729596 @default.
• W2968794930 cites W2034269086 @default.
• W2968794930 cites W2072672778 @default.
• W2968794930 cites W2077954334 @default.
• W2968794930 cites W2083166156 @default.
• W2968794930 cites W2102145679 @default.
• W2968794930 cites W2116196276 @default.
• W2968794930 cites W2127911529 @default.
• W2968794930 cites W2144332042 @default.
• W2968794930 cites W2180117953 @default.
• W2968794930 cites W2276035669 @default.
• W2968794930 cites W2313659012 @default.
• W2968794930 cites W2328491406 @default.
• W2968794930 cites W2485355719 @default.
• W2968794930 cites W2525955593 @default.
• W2968794930 cites W2605431828 @default.
• W2968794930 cites W2781525129 @default.
• W2968794930 cites W2791159567 @default.
• W2968794930 cites W2794263726 @default.
• W2968794930 cites W2900102888 @default.
• W2968794930 cites W2923867048 @default.
• W2968794930 doi "https://doi.org/10.3390/pharmaceutics11080408" @default.
• W2968794930 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6722936" @default.
• W2968794930 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31408964" @default.
• W2968794930 hasPublicationYear "2019" @default.
• W2968794930 type Work @default.
• W2968794930 sameAs 2968794930 @default.
• W2968794930 citedByCount "20" @default.
• W2968794930 countsByYear W29687949302020 @default.
• W2968794930 countsByYear W29687949302021 @default.
• W2968794930 countsByYear W29687949302022 @default.
• W2968794930 countsByYear W29687949302023 @default.
• W2968794930 crossrefType "journal-article" @default.
• W2968794930 hasAuthorship W2968794930A5002952053 @default.
• W2968794930 hasAuthorship W2968794930A5006370304 @default.
• W2968794930 hasAuthorship W2968794930A5008212945 @default.
• W2968794930 hasAuthorship W2968794930A5018486980 @default.
• W2968794930 hasAuthorship W2968794930A5039994623 @default.
• W2968794930 hasAuthorship W2968794930A5041304639 @default.
• W2968794930 hasAuthorship W2968794930A5063699642 @default.
• W2968794930 hasAuthorship W2968794930A5072312871 @default.
• W2968794930 hasAuthorship W2968794930A5082312617 @default.
• W2968794930 hasAuthorship W2968794930A5083770622 @default.
• W2968794930 hasAuthorship W2968794930A5088496504 @default.
• W2968794930 hasBestOaLocation W29687949301 @default.
• W2968794930 hasConcept C121608353 @default.
• W2968794930 hasConcept C12554922 @default.
• W2968794930 hasConcept C1491633281 @default.
• W2968794930 hasConcept C18150654 @default.
• W2968794930 hasConcept C185592680 @default.
• W2968794930 hasConcept C2776330855 @default.
• W2968794930 hasConcept C2778918659 @default.
• W2968794930 hasConcept C2780035454 @default.
• W2968794930 hasConcept C2780601828 @default.
• W2968794930 hasConcept C2781123555 @default.
• W2968794930 hasConcept C28005876 @default.
• W2968794930 hasConcept C41625074 @default.
• W2968794930 hasConcept C54355233 @default.
• W2968794930 hasConcept C55493867 @default.
• W2968794930 hasConcept C86803240 @default.
• W2968794930 hasConcept C96232424 @default.
• W2968794930 hasConcept C98274493 @default.
• W2968794930 hasConceptScore W2968794930C121608353 @default.
• W2968794930 hasConceptScore W2968794930C12554922 @default.
• W2968794930 hasConceptScore W2968794930C1491633281 @default.
• W2968794930 hasConceptScore W2968794930C18150654 @default.
• W2968794930 hasConceptScore W2968794930C185592680 @default.
• W2968794930 hasConceptScore W2968794930C2776330855 @default.
• W2968794930 hasConceptScore W2968794930C2778918659 @default.
• W2968794930 hasConceptScore W2968794930C2780035454 @default.
• W2968794930 hasConceptScore W2968794930C2780601828 @default.
• W2968794930 hasConceptScore W2968794930C2781123555 @default.
• W2968794930 hasConceptScore W2968794930C28005876 @default.
• W2968794930 hasConceptScore W2968794930C41625074 @default.
• W2968794930 hasConceptScore W2968794930C54355233 @default.
• W2968794930 hasConceptScore W2968794930C55493867 @default.
• W2968794930 hasConceptScore W2968794930C86803240 @default.

• next