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- W2968798605 abstract "A series of water-soluble cationic chalcogenoviologen-based photosensitizers for photodynamic antimicrobial therapy (PDAT) is reported. The Se-containing derivatives (SeMV2+) 5 b and 6 b showed good antimicrobial activities due to the presence of chalcogen atoms and a cationic scaffold. The former efficiently enhanced the generation of reactive oxygen species (ROS), and the latter facilitated the ROS delivery to bacteria, resulting in their death. Interestingly, alkyl-modified photosensitizers showed higher antimicrobial activities than commonly reported photosensitizers with quaternary ammonium (QA) groups. In particular, the SeMV2+ (6 b) with excellent antibacterial activities efficiently promoted the healing of infected wounds in mice. Simple yet novel, nontoxic and biocompatible chalcogenoviologens provided a promising strategy to develop new efficient photosensitizers for photodynamic antimicrobial therapy and skin regeneration." @default.
- W2968798605 created "2019-08-22" @default.
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- W2968798605 date "2019-08-28" @default.
- W2968798605 modified "2023-10-13" @default.
- W2968798605 title "Cationic Chalcogenoviologen Derivatives for Photodynamic Antimicrobial Therapy and Skin Regeneration" @default.
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- W2968798605 doi "https://doi.org/10.1002/chem.201903278" @default.
- W2968798605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31393035" @default.
- W2968798605 hasPublicationYear "2019" @default.