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- W2968800814 abstract "(1) Background: Nutrition is a major lifestyle factor that can prevent the risk of cognitive impairment and dementia. Diet-induced metabolic endotoxemia has been proposed as a major root cause of inflammation and these pathways emerge as detrimental factors of healthy ageing. The aim of this paper was to update research focusing on the relationship between a fat-rich diet and endotoxemia, and to discuss the potential role of endotoxemia in cognitive performances. (2) Methods: We conducted a non-systematic literature review based on the PubMed database related to fat-rich meals, metabolic endotoxemia and cognitive disorders including dementia in humans. A total of 40 articles out of 942 in the first screening met the inclusion criteria. (3) Results: Evidence suggested that a fat-rich diet, depending on its quality, quantity and concomitant healthy food components, could influence metabolic endotoxemia. Since only heterogeneous cross-sectional studies are available, it remains unclear to what extent endotoxemia could be associated or not with cognitive disorders and dementia. (4) Conclusions: A fat-rich diet has the capability to provide significant increases in circulating endotoxins, which highlights nutritional strategies as a promising area for future research on inflammatory-associated diseases. The role of endotoxemia in cognitive disorders and dementia remains unclear and deserves further investigation." @default.
- W2968800814 created "2019-08-22" @default.
- W2968800814 creator A5001654955 @default.
- W2968800814 creator A5025340334 @default.
- W2968800814 creator A5025723535 @default.
- W2968800814 date "2019-08-13" @default.
- W2968800814 modified "2023-10-18" @default.
- W2968800814 title "Metabolic Endotoxemia: A Potential Underlying Mechanism of the Relationship between Dietary Fat Intake and Risk for Cognitive Impairments in Humans?" @default.
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- W2968800814 doi "https://doi.org/10.3390/nu11081887" @default.
- W2968800814 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6722750" @default.
- W2968800814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31412673" @default.
- W2968800814 hasPublicationYear "2019" @default.
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