FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968806891> ?p ?o ?g. }

• W2968806891 abstract "Tubeimoside-I (TBM), a plant-derived bioactive compound, shows antitumor activity in different tumors and can enhance the efficacy of chemotherapeutic agents. However, the detail mechanism underlying remains to be elucidated. The cytotoxic potential of TBM towards CRC cells was examined by CCK8 assay, colony formation, LDH release assay, flow cytometry method and Western blots. The ROS levels, autophagy, apoptosis, chemosensitivity to 5-FU or DOX, etc. were determined between control and TBM-treated CRC cells. In this study, we found that TBM could inhibit proliferation and induce apoptosis in colorectal cancer (CRC) cells. Intriguingly, TBM treatment could either promote autophagy initiation by ROS-induced AMPK activation, or block autophagy flux through inhibiting lysosomal hydrolytic enzymes, which leaded to massive impaired autophagylysosomes accumulation. Administration of autophagy initiation inhibitor (3-MA or selective ablation of autophagy related proteins) relieves TBM-induced CRC suppression, while combination use of autophagy flux inhibitor chloroquine (CQ) slightly augments TBM-induced cell death, suggesting that impaired autophagylysosomes accumulation contributes to TBM-induced growth inhibition in CRC cells. Notably, as an autophagy flux inhibitor, TBM works synergistically with 5-fluorouracil (5-FU) or doxorubicin (DOX) in CRC suppression. Together, our study provides new insights regarding the anti-tumor activity of TBM against CRC, and established potential applications of TBM for CRC combination therapies in clinic." @default.
• W2968806891 created "2019-08-22" @default.
• W2968806891 creator A5001497574 @default.
• W2968806891 creator A5015671255 @default.
• W2968806891 creator A5017642778 @default.
• W2968806891 creator A5019344890 @default.
• W2968806891 creator A5035822423 @default.
• W2968806891 creator A5050405673 @default.
• W2968806891 creator A5086354231 @default.
• W2968806891 date "2019-08-14" @default.
• W2968806891 modified "2023-10-12" @default.
• W2968806891 title "Tubeimoside-I sensitizes colorectal cancer cells to chemotherapy by inducing ROS-mediated impaired autophagolysosomes accumulation" @default.
• W2968806891 cites W1523693806 @default.
• W2968806891 cites W1578854399 @default.
• W2968806891 cites W1922145593 @default.
• W2968806891 cites W1970637701 @default.
• W2968806891 cites W1992189952 @default.
• W2968806891 cites W2003396960 @default.
• W2968806891 cites W2008472606 @default.
• W2968806891 cites W2009101631 @default.
• W2968806891 cites W2025061635 @default.
• W2968806891 cites W2035401962 @default.
• W2968806891 cites W2048571348 @default.
• W2968806891 cites W2055811314 @default.
• W2968806891 cites W2070852285 @default.
• W2968806891 cites W2079351077 @default.
• W2968806891 cites W2086668210 @default.
• W2968806891 cites W2123388712 @default.
• W2968806891 cites W2132035769 @default.
• W2968806891 cites W2160615487 @default.
• W2968806891 cites W2239175614 @default.
• W2968806891 cites W2337653414 @default.
• W2968806891 cites W2416965099 @default.
• W2968806891 cites W2418403232 @default.
• W2968806891 cites W2422314397 @default.
• W2968806891 cites W2430709944 @default.
• W2968806891 cites W2588451433 @default.
• W2968806891 cites W2594373254 @default.
• W2968806891 cites W2624666184 @default.
• W2968806891 cites W2740618823 @default.
• W2968806891 cites W2752326209 @default.
• W2968806891 cites W2762043727 @default.
• W2968806891 cites W2888986739 @default.
• W2968806891 cites W2889646458 @default.
• W2968806891 cites W2896935164 @default.
• W2968806891 cites W2899270033 @default.
• W2968806891 cites W2899377519 @default.
• W2968806891 cites W2913870207 @default.
• W2968806891 cites W2915478882 @default.
• W2968806891 cites W4211199921 @default.
• W2968806891 doi "https://doi.org/10.1186/s13046-019-1355-0" @default.
• W2968806891 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6694658" @default.
• W2968806891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31412953" @default.
• W2968806891 hasPublicationYear "2019" @default.
• W2968806891 type Work @default.
• W2968806891 sameAs 2968806891 @default.
• W2968806891 citedByCount "26" @default.
• W2968806891 countsByYear W29688068912019 @default.
• W2968806891 countsByYear W29688068912020 @default.
• W2968806891 countsByYear W29688068912021 @default.
• W2968806891 countsByYear W29688068912022 @default.
• W2968806891 countsByYear W29688068912023 @default.
• W2968806891 crossrefType "journal-article" @default.
• W2968806891 hasAuthorship W2968806891A5001497574 @default.
• W2968806891 hasAuthorship W2968806891A5015671255 @default.
• W2968806891 hasAuthorship W2968806891A5017642778 @default.
• W2968806891 hasAuthorship W2968806891A5019344890 @default.
• W2968806891 hasAuthorship W2968806891A5035822423 @default.
• W2968806891 hasAuthorship W2968806891A5050405673 @default.
• W2968806891 hasAuthorship W2968806891A5086354231 @default.
• W2968806891 hasBestOaLocation W29688068911 @default.
• W2968806891 hasConcept C121608353 @default.
• W2968806891 hasConcept C126322002 @default.
• W2968806891 hasConcept C178790620 @default.
• W2968806891 hasConcept C185592680 @default.
• W2968806891 hasConcept C190283241 @default.
• W2968806891 hasConcept C203014093 @default.
• W2968806891 hasConcept C203522944 @default.
• W2968806891 hasConcept C2776694085 @default.
• W2968806891 hasConcept C2781303535 @default.
• W2968806891 hasConcept C31573885 @default.
• W2968806891 hasConcept C502942594 @default.
• W2968806891 hasConcept C526805850 @default.
• W2968806891 hasConcept C553184892 @default.
• W2968806891 hasConcept C55493867 @default.
• W2968806891 hasConcept C68709404 @default.
• W2968806891 hasConcept C71924100 @default.
• W2968806891 hasConcept C96232424 @default.
• W2968806891 hasConcept C98274493 @default.
• W2968806891 hasConceptScore W2968806891C121608353 @default.
• W2968806891 hasConceptScore W2968806891C126322002 @default.
• W2968806891 hasConceptScore W2968806891C178790620 @default.
• W2968806891 hasConceptScore W2968806891C185592680 @default.
• W2968806891 hasConceptScore W2968806891C190283241 @default.
• W2968806891 hasConceptScore W2968806891C203014093 @default.
• W2968806891 hasConceptScore W2968806891C203522944 @default.
• W2968806891 hasConceptScore W2968806891C2776694085 @default.
• W2968806891 hasConceptScore W2968806891C2781303535 @default.
• W2968806891 hasConceptScore W2968806891C31573885 @default.
• W2968806891 hasConceptScore W2968806891C502942594 @default.

• next