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- W2968808564 abstract "Abstract Observation of single molecules requires probing a sample volume that contains no more than one molecule at a time. For diffraction-limited probe volumes this requires molecular concentrations that may be incompatible with the biological system being interrogated. In this chapter we describe the use of nanofluidic devices as an alternative approach to restrict probe volumes below diffraction-limited values. In particular, we will focus on the use of nanoscale devices for the detection and optical mapping of single DNA molecules. The chapter describes unique electrokinetic phenomena that emerge on the nanoscale as well. The driving forces for fluid flow and interactions with the fluid via walls are qualitatively different on the nanoscale as compared to the microscale. Overlap of the electric double layers generated by opposite walls on the nanoscale alters the velocity profile (plug-like on the microscale to parabolic on the nanoscale for electrokinetic flows). The conformation of DNA is sensitive to channel dimensions. In nanochannels, DNA molecules stretch to nearly their full contour length when the channel dimensions are comparable to the persistence length of the DNA molecule. Methods of fabrication of nanochannel devices are surveyed. Electron beam lithography, focused ion beam milling, and nanoimprint lithography have been used to generate nanoscale devices. Finally, we describe recent applications of fluorescence imaging of single molecules in nanochannels for optical mapping of DNA and the detection of sequence variations." @default.
- W2968808564 created "2019-08-22" @default.
- W2968808564 creator A5028626711 @default.
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- W2968808564 creator A5063758959 @default.
- W2968808564 date "2019-01-01" @default.
- W2968808564 modified "2023-09-26" @default.
- W2968808564 title "Single molecule analysis in nanofluidic devices" @default.
- W2968808564 cites W1501261314 @default.
- W2968808564 cites W1505696417 @default.
- W2968808564 cites W1964312606 @default.
- W2968808564 cites W1964618039 @default.
- W2968808564 cites W1966043962 @default.
- W2968808564 cites W1968161404 @default.
- W2968808564 cites W1968582026 @default.
- W2968808564 cites W1970015694 @default.
- W2968808564 cites W1971528483 @default.
- W2968808564 cites W1973013237 @default.
- W2968808564 cites W1973029267 @default.
- W2968808564 cites W1977611025 @default.
- W2968808564 cites W1980284953 @default.
- W2968808564 cites W1982216260 @default.
- W2968808564 cites W1983874432 @default.
- W2968808564 cites W1987245731 @default.
- W2968808564 cites W1988266816 @default.
- W2968808564 cites W1988502493 @default.
- W2968808564 cites W1989568035 @default.
- W2968808564 cites W1991642760 @default.
- W2968808564 cites W1993979141 @default.
- W2968808564 cites W1994980002 @default.
- W2968808564 cites W1996655685 @default.
- W2968808564 cites W1998431939 @default.
- W2968808564 cites W2000031891 @default.
- W2968808564 cites W2002042493 @default.
- W2968808564 cites W2004392673 @default.
- W2968808564 cites W2005485153 @default.
- W2968808564 cites W2007096907 @default.
- W2968808564 cites W2008062614 @default.
- W2968808564 cites W2008821017 @default.
- W2968808564 cites W2012012446 @default.
- W2968808564 cites W2015718026 @default.
- W2968808564 cites W2017001472 @default.
- W2968808564 cites W2021524730 @default.
- W2968808564 cites W2021581431 @default.
- W2968808564 cites W2021622572 @default.
- W2968808564 cites W2022503160 @default.
- W2968808564 cites W2022815376 @default.
- W2968808564 cites W2023410143 @default.
- W2968808564 cites W2024857462 @default.
- W2968808564 cites W2025439784 @default.
- W2968808564 cites W2026830057 @default.
- W2968808564 cites W2027539634 @default.
- W2968808564 cites W2028040523 @default.
- W2968808564 cites W2029801201 @default.
- W2968808564 cites W2031130615 @default.
- W2968808564 cites W2031167698 @default.
- W2968808564 cites W2031335278 @default.
- W2968808564 cites W2031387252 @default.
- W2968808564 cites W2032332857 @default.
- W2968808564 cites W2036282665 @default.
- W2968808564 cites W2036799251 @default.
- W2968808564 cites W2039333678 @default.
- W2968808564 cites W2040820046 @default.
- W2968808564 cites W2042238140 @default.
- W2968808564 cites W2045435533 @default.
- W2968808564 cites W2046746676 @default.
- W2968808564 cites W2047102627 @default.
- W2968808564 cites W2048509789 @default.
- W2968808564 cites W2048558511 @default.
- W2968808564 cites W2049522952 @default.
- W2968808564 cites W2050039952 @default.
- W2968808564 cites W2053563183 @default.
- W2968808564 cites W2054460607 @default.
- W2968808564 cites W2060726880 @default.
- W2968808564 cites W2062047511 @default.
- W2968808564 cites W2062074587 @default.
- W2968808564 cites W2062900575 @default.
- W2968808564 cites W2066386767 @default.
- W2968808564 cites W2067967098 @default.
- W2968808564 cites W2068433164 @default.
- W2968808564 cites W2072050287 @default.
- W2968808564 cites W2072419120 @default.
- W2968808564 cites W2072813448 @default.
- W2968808564 cites W2075569108 @default.
- W2968808564 cites W2077554211 @default.
- W2968808564 cites W2078241716 @default.
- W2968808564 cites W2078298270 @default.
- W2968808564 cites W2078528364 @default.
- W2968808564 cites W2082818998 @default.
- W2968808564 cites W2083884931 @default.
- W2968808564 cites W2085369712 @default.
- W2968808564 cites W2090588117 @default.
- W2968808564 cites W2091882341 @default.
- W2968808564 cites W2093517242 @default.
- W2968808564 cites W2095574592 @default.
- W2968808564 cites W2099357929 @default.