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- W2968814946 abstract "Mesenchymal stem cells (MSCs) participate in the regeneration of tissue lesions induced by antimetabolite chemotherapy; however, the influence of this class of anti-cancer compounds on the stem cells remains largely unknown. The survival of MSCs after exposure to 5-fluorouracil (5-FU) and gemcitabine was measured by viability and clonogenic assays. MSC morphology, surface marker expression, adhesion potential, cellular velocity and differentiation potential were determined after antimetabolite treatment. Cell cycle distribution and apoptosis were assessed using flow cytometry, and senescence induction was evaluated by beta-galactosidase staining. Gene expression arrays were used to analyze the expression of enzymes involved in DNA metabolism and multidrug resistance. Here, we show that human primary bone marrow MSCs are relatively resistant to treatment with the widely used antimetabolite drugs 5-FU and gemcitabine. The stem cells were able to largely retain their functional abilities and defining stem cell traits after antimetabolite exposure. MSCs surface markers were found stably expressed, and the characteristic multi-lineage differentiation potential was maintained irrespective of 5-FU or gemcitabine treatment. High expression levels of enzymes involved in DNA metabolism and multidrug resistance transporters may contribute to the resistance to antimetabolite chemotherapy. The observed resistance and functional integrity may form the basis for further investigations of MSCs as a potential therapy for antimetabolite-induced tissue damage." @default.
- W2968814946 created "2019-08-22" @default.
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- W2968814946 date "2019-10-01" @default.
- W2968814946 modified "2023-09-23" @default.
- W2968814946 title "Mesenchymal stem cells preserve their stem cell traits after exposure to antimetabolite chemotherapy" @default.
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- W2968814946 cites W1984328540 @default.
- W2968814946 cites W1993252085 @default.
- W2968814946 cites W2008510535 @default.
- W2968814946 cites W2011058197 @default.
- W2968814946 cites W2012701731 @default.
- W2968814946 cites W2020961814 @default.
- W2968814946 cites W2021583973 @default.
- W2968814946 cites W2023532828 @default.
- W2968814946 cites W2023722318 @default.
- W2968814946 cites W2025371271 @default.
- W2968814946 cites W2026187026 @default.
- W2968814946 cites W2035486075 @default.
- W2968814946 cites W2037651383 @default.
- W2968814946 cites W2042552285 @default.
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- W2968814946 doi "https://doi.org/10.1016/j.scr.2019.101536" @default.
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