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- W2968831837 abstract "Significance The endoplasmic reticulum (ER) deteriorates with age and fails to mount an effective stress response against misfolded proteins (UPR ER ), leading to protein folding disorders. However, preconditioning the ER using a mild ER stress (ER hormesis) can protect against future insults. We show that dietary restriction, an intervention that protects against protein misfolding disorders and increases life span across species, uses ER hormesis as a mechanism of action. Simply mimicking the ER hormesis in Caenorhabditis elegans by transient treatment with pharmacological reagents leads to delayed age-onset failure of UPR ER , better capacity to process misfolded proteins, and increased life span. We also show that this process may be conserved in a mammalian cellular model of neurodegenerative disease." @default.
- W2968831837 created "2019-08-22" @default.
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- W2968831837 date "2019-08-14" @default.
- W2968831837 modified "2023-10-01" @default.
- W2968831837 title "Dietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis" @default.
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- W2968831837 doi "https://doi.org/10.1073/pnas.1900055116" @default.
- W2968831837 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6717303" @default.
- W2968831837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31413197" @default.
- W2968831837 hasPublicationYear "2019" @default.
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