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• W2968850985 startingPage "103194" @default.
• W2968850985 abstract "Cathepsin B plays key roles in tumor progression with its overexpression being associated with invasive and metastatic phenotypes and is a primary target of protease activated antibody-directed prodrug therapy. It therefore represents a potential therapeutic and diagnostic target and effort has been made to develop fluorescent probes to report on Cathepsin B activity in cells and animal models of cancer. We have designed, synthesized, and thoroughly evaluated four novel turn on probes that employ a lysosomotropic dansylcadaverine dye to report on Cathepsin B activity. Enzyme activity assays using a recombinant human enzyme and cancer cell lysates coupled with confocal microscopy experiments demonstrated that one of the probes, derivatized with the self-immolative prodrug linker p-aminobenzyl alcohol, can selectively report on Cathepsin B in biological samples including live cells." @default.
• W2968850985 created "2019-08-22" @default.
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• W2968850985 date "2019-11-01" @default.
• W2968850985 modified "2023-09-27" @default.
• W2968850985 title "Design and synthesis of fluorogenic substrate-based probes for detecting Cathepsin B activity" @default.
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• W2968850985 doi "https://doi.org/10.1016/j.bioorg.2019.103194" @default.
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