Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968863911> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2968863911 abstract "Abstract PURPOSE: The results of the RTOG 0933 and NRG CC001 clinical trials have shown that physical sparing of the hippocampus during cranial irradiation (CI) is associated with preservation of memory functions at 4- and 6-months following therapy. Whereas the putative roles of protection of neural stem cells (NSCs) residing within the subgranular zone (SGZ) of the dentate gyrus are presently poorly defined, suppression of inflammation may be involved because ablation of microglia (MG) through blockade of the CSF-1R or selective targeting of CCR2+ macrophages using an appropriate CCR2 inhibitor leads to the retention of hippocampal-dependent cognitive abilities following CI. Inhibition of Colony stimulating factor 2 (CSF-2), a proinflammatory cytokine causing the proliferation and activation of microglia, may be a suitable alternative strategy to alleviate inflammation. METHODS: Our studies have evaluated the effects of ablation of Csf2 and also the inducible ablation of MG on the properties of neuroinflammation, neurogenesis and CI-associated cognitive impairments employing the requisite mouse models. RESULTS: We demonstrate that preservation of cognitive functions following CI does not require ablation of MG. In addition, the reduction in neuroinflammation following Csf2ablation was sufficient to prevent CI-induced cognitive decline. Moreover, Csf2 ablation did not prevent the deficit in neurogenesis, thereby suggesting that NSC-mediated SGZ neurogenesis is not required for the prevention of radiation-induced cognitive dysfunction. CONCLUSION: We have previously shown that MG play seminal roles in neural development and adult homeostasis and plasticity. Our present study demonstrates that selective modulation of MG-associated neuroinflammatory signaling without MG ablation is a novel therapeutic strategy to preserve cognitive functions following CI. These experimental observations have seminal implications for patients undergoing radiation therapy for tumors of the brain or head and neck in which the hippocampus inevitably exposed to a high dose of radiation leading to potentially debilitating and possibly avoidable cognitive deficits." @default.
- W2968863911 created "2019-08-22" @default.
- W2968863911 creator A5005071523 @default.
- W2968863911 creator A5007635759 @default.
- W2968863911 creator A5023209696 @default.
- W2968863911 creator A5052817440 @default.
- W2968863911 creator A5053707581 @default.
- W2968863911 creator A5060336953 @default.
- W2968863911 creator A5067532058 @default.
- W2968863911 creator A5082722222 @default.
- W2968863911 date "2019-08-01" @default.
- W2968863911 modified "2023-10-18" @default.
- W2968863911 title "BSCI-18. ABLATION OF Csf2 MITIGATES RADIATION-INDUCED NEUROCOGNITIVE DECLINE INDEPENDENT OF HIPPOCAMPAL NEUROGENESIS" @default.
- W2968863911 doi "https://doi.org/10.1093/noajnl/vdz014.016" @default.
- W2968863911 hasPublicationYear "2019" @default.
- W2968863911 type Work @default.
- W2968863911 sameAs 2968863911 @default.
- W2968863911 citedByCount "0" @default.
- W2968863911 crossrefType "journal-article" @default.
- W2968863911 hasAuthorship W2968863911A5005071523 @default.
- W2968863911 hasAuthorship W2968863911A5007635759 @default.
- W2968863911 hasAuthorship W2968863911A5023209696 @default.
- W2968863911 hasAuthorship W2968863911A5052817440 @default.
- W2968863911 hasAuthorship W2968863911A5053707581 @default.
- W2968863911 hasAuthorship W2968863911A5060336953 @default.
- W2968863911 hasAuthorship W2968863911A5067532058 @default.
- W2968863911 hasAuthorship W2968863911A5082722222 @default.
- W2968863911 hasBestOaLocation W29688639111 @default.
- W2968863911 hasConcept C126322002 @default.
- W2968863911 hasConcept C148762608 @default.
- W2968863911 hasConcept C15744967 @default.
- W2968863911 hasConcept C169760540 @default.
- W2968863911 hasConcept C169900460 @default.
- W2968863911 hasConcept C172467417 @default.
- W2968863911 hasConcept C2778902805 @default.
- W2968863911 hasConcept C2781161787 @default.
- W2968863911 hasConcept C4746552 @default.
- W2968863911 hasConcept C71924100 @default.
- W2968863911 hasConceptScore W2968863911C126322002 @default.
- W2968863911 hasConceptScore W2968863911C148762608 @default.
- W2968863911 hasConceptScore W2968863911C15744967 @default.
- W2968863911 hasConceptScore W2968863911C169760540 @default.
- W2968863911 hasConceptScore W2968863911C169900460 @default.
- W2968863911 hasConceptScore W2968863911C172467417 @default.
- W2968863911 hasConceptScore W2968863911C2778902805 @default.
- W2968863911 hasConceptScore W2968863911C2781161787 @default.
- W2968863911 hasConceptScore W2968863911C4746552 @default.
- W2968863911 hasConceptScore W2968863911C71924100 @default.
- W2968863911 hasLocation W29688639111 @default.
- W2968863911 hasLocation W29688639112 @default.
- W2968863911 hasOpenAccess W2968863911 @default.
- W2968863911 hasPrimaryLocation W29688639111 @default.
- W2968863911 hasRelatedWork W1976774123 @default.
- W2968863911 hasRelatedWork W1985899045 @default.
- W2968863911 hasRelatedWork W2045162649 @default.
- W2968863911 hasRelatedWork W2054552572 @default.
- W2968863911 hasRelatedWork W2113120301 @default.
- W2968863911 hasRelatedWork W2312660731 @default.
- W2968863911 hasRelatedWork W2334684221 @default.
- W2968863911 hasRelatedWork W2516403679 @default.
- W2968863911 hasRelatedWork W2619025546 @default.
- W2968863911 hasRelatedWork W2747436811 @default.
- W2968863911 hasRelatedWork W2753539832 @default.
- W2968863911 hasRelatedWork W2909923605 @default.
- W2968863911 hasRelatedWork W2973342065 @default.
- W2968863911 hasRelatedWork W2974662906 @default.
- W2968863911 hasRelatedWork W2991970230 @default.
- W2968863911 hasRelatedWork W3021755978 @default.
- W2968863911 hasRelatedWork W3035534356 @default.
- W2968863911 hasRelatedWork W3039872813 @default.
- W2968863911 hasRelatedWork W3091903672 @default.
- W2968863911 hasRelatedWork W3118135022 @default.
- W2968863911 isParatext "false" @default.
- W2968863911 isRetracted "false" @default.
- W2968863911 magId "2968863911" @default.
- W2968863911 workType "article" @default.