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• W2968867377 endingPage "101221" @default.
• W2968867377 startingPage "101221" @default.
• W2968867377 abstract "Griseofulvin (GF) is a poor aqueous soluble and high permeability drug, are classified as a Class II drugs based on the Biopharmaceutical Classification System (BCS). Recently, GF has gained attention in the biomedical sector due to its ability to disrupt mitotic spindles and act as a potential inhibitor of centrosomal clustering in tumor cells. Poor water solubility of a drug typically limits its therapeutic applications. There are different technologies available, one promising method is through nanoparticle preparation. A brief review of the literature of GF nanoformulations through milling, high pressure homogenization, spray/freeze drying, emulsion solvent evaporation, antisolvent precipitation, and supercritical fluid processes is provided. The review also provides a discussion of lipid-based formulations and silica nanostructures-based formulations to improve solubility and bioavailability of GF. From the literature it is clear that milling, high pressure homogenization, lipid based formulations are promising techniques for commercialization. Further advancement and control experimental design to yield high solid loading and continuous nanocrystallization can makes antisolvent precipitation method suitable for industrial applications. Compare to silica, lipid based formulations are less toxic. A brief note on commercial products available in the market also summarized. This review can serve as a platform for further investigation of GF nanoformulation." @default.
• W2968867377 created "2019-08-22" @default.
• W2968867377 creator A5073510537 @default.
• W2968867377 date "2019-10-01" @default.
• W2968867377 modified "2023-10-13" @default.
• W2968867377 title "Nanotechnology based approaches to enhance aqueous solubility and bioavailability of griseofulvin: A literature survey" @default.
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