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- W2968872536 abstract "Cell-cell communication via ligand-receptor signaling is a fundamental feature of complex organs. Despite this, the global landscape of intercellular signaling in mammalian liver has not been elucidated. Here we perform single-cell RNA sequencing on non-parenchymal cells isolated from healthy and NASH mouse livers. Secretome gene analysis revealed a highly connected network of intrahepatic signaling and disruption of vascular signaling in NASH. We uncovered the emergence of NASH-associated macrophages (NAMs), which are marked by high expression of triggering receptors expressed on myeloid cells 2 (Trem2), as a feature of mouse and human NASH that is linked to disease severity and highly responsive to pharmacological and dietary interventions. Finally, hepatic stellate cells (HSCs) serve as a hub of intrahepatic signaling via HSC-derived stellakines and their responsiveness to vasoactive hormones. These results provide unprecedented insights into the landscape of intercellular crosstalk and reprogramming of liver cells in health and disease." @default.
- W2968872536 created "2019-08-22" @default.
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- W2968872536 date "2019-08-01" @default.
- W2968872536 modified "2023-10-18" @default.
- W2968872536 title "Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis" @default.
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- W2968872536 doi "https://doi.org/10.1016/j.molcel.2019.07.028" @default.
- W2968872536 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7262680" @default.
- W2968872536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31398325" @default.
- W2968872536 hasPublicationYear "2019" @default.