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• W2968882583 endingPage "2985" @default.
• W2968882583 startingPage "2985" @default.
• W2968882583 abstract "Ginsenoside Ro (Ro), a major saponin derived and isolated from Panax ginseng C.A. Meyer, exerts multiple biological activities. However, the anti-tumour efficacy of Ro remains unclear because of its poor in vitro effects. In this study, we confirmed that Ro has no anti-tumour activity in vitro. We explored the anti-tumour activity of Ro in vivo in B16F10 tumour-bearing mice. The results revealed that Ro considerably suppressed tumour growth with no significant side effects on immune organs and body weight. Zingibroside R1, chikusetsusaponin IVa, and calenduloside E, three metabolites of Ro, were detected in the plasma of Ro-treated tumour-bearing mice and showed excellent anti-tumour effects as well as anti-angiogenic activity. The results suggest that the metabolites play important roles in the anti-tumour efficacy of Ro in vivo. Additionally, the haemolysis test demonstrated that Ro has good biocompatibility. Taken together, the findings of this study demonstrate that Ro markedly suppresses the tumour growth of B16F10-transplanted tumours in vivo, and its anti-tumour effects are based on the biological activity of its metabolites. The anti-tumour efficacy of these metabolites is due, at least in part, to its anti-angiogenic activity." @default.
• W2968882583 created "2019-08-22" @default.
• W2968882583 creator A5004103610 @default.
• W2968882583 creator A5008897623 @default.
• W2968882583 creator A5041492237 @default.
• W2968882583 creator A5054352845 @default.
• W2968882583 creator A5057492548 @default.
• W2968882583 date "2019-08-17" @default.
• W2968882583 modified "2023-10-16" @default.
• W2968882583 title "Inhibitory Effects of Ginsenoside Ro on the Growth of B16F10 Melanoma via Its Metabolites" @default.
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• W2968882583 cites W1426808605 @default.
• W2968882583 cites W1854555833 @default.
• W2968882583 cites W1896527885 @default.
• W2968882583 cites W1911028454 @default.
• W2968882583 cites W1935967979 @default.
• W2968882583 cites W1971507232 @default.
• W2968882583 cites W1975126843 @default.
• W2968882583 cites W1979823716 @default.
• W2968882583 cites W1981386921 @default.
• W2968882583 cites W1983719849 @default.
• W2968882583 cites W1992270353 @default.
• W2968882583 cites W1993416464 @default.
• W2968882583 cites W1994637146 @default.
• W2968882583 cites W1997262737 @default.
• W2968882583 cites W1997458757 @default.
• W2968882583 cites W1997691932 @default.
• W2968882583 cites W1999013309 @default.
• W2968882583 cites W2003838432 @default.
• W2968882583 cites W2005412956 @default.
• W2968882583 cites W2017616929 @default.
• W2968882583 cites W2024255080 @default.
• W2968882583 cites W2028335552 @default.
• W2968882583 cites W2029096573 @default.
• W2968882583 cites W2031648987 @default.
• W2968882583 cites W2043008926 @default.
• W2968882583 cites W2043752864 @default.
• W2968882583 cites W2057776973 @default.
• W2968882583 cites W2062176772 @default.
• W2968882583 cites W2064665896 @default.
• W2968882583 cites W2065013586 @default.
• W2968882583 cites W2068389461 @default.
• W2968882583 cites W2074260494 @default.
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• W2968882583 cites W2099674544 @default.
• W2968882583 cites W2114850456 @default.
• W2968882583 cites W2116472473 @default.
• W2968882583 cites W2116677194 @default.
• W2968882583 cites W2118727180 @default.
• W2968882583 cites W2118750456 @default.
• W2968882583 cites W2121003886 @default.
• W2968882583 cites W2140364774 @default.
• W2968882583 cites W2213937043 @default.
• W2968882583 cites W2294392129 @default.
• W2968882583 cites W2312493162 @default.
• W2968882583 cites W2313852360 @default.
• W2968882583 cites W2331086861 @default.
• W2968882583 cites W2340254794 @default.
• W2968882583 cites W2414284584 @default.
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• W2968882583 cites W2466641658 @default.
• W2968882583 cites W2512046398 @default.
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• W2968882583 cites W2742372504 @default.
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• W2968882583 cites W2765807059 @default.
• W2968882583 cites W2768613074 @default.
• W2968882583 cites W2771428152 @default.
• W2968882583 cites W2773635312 @default.
• W2968882583 cites W2791232791 @default.
• W2968882583 cites W2791509726 @default.
• W2968882583 cites W2792159386 @default.
• W2968882583 cites W2793558613 @default.
• W2968882583 cites W2796077954 @default.
• W2968882583 cites W2803517616 @default.
• W2968882583 cites W2807201667 @default.
• W2968882583 cites W2809114926 @default.
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• W2968882583 cites W2892401707 @default.
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• W2968882583 doi "https://doi.org/10.3390/molecules24162985" @default.
• W2968882583 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6721120" @default.
• W2968882583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31426477" @default.
• W2968882583 hasPublicationYear "2019" @default.
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