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• W2968884857 abstract "Four isomeric dehydroepiandrosterone- and pregnenolone-based N-alkynylaminosteroids were synthesized and tested in vitro for inhibition of heterologously expressed CYP17A1. The highest inhibitory activity was observed when the optimal number of side chain atoms was met. The conjugate based on pregnenolone containing an N-propynyl moiety was found to interefere with enzymatic activity most effectively and consistently in the micromolar range." @default.
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• W2968884857 date "2019-01-01" @default.
• W2968884857 modified "2023-10-12" @default.
• W2968884857 title "Synthesis and evaluation of N-alkynylaminosteroids as potential CYP450 17A1 inhibitors" @default.
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• W2968884857 doi "https://doi.org/10.18097/pbmc20196504324" @default.
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