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• W2968902133 abstract "Cyclic lipodepsipeptides (CLPs) are non-ribosomal bacterial peptides, which exhibit antagonistic activity against several bacterial and fungal species. CLPs increasingly attract attention in the field of crop protection, where they serve as valuable alternatives to chemical pesticides. A full understanding of their conformation and membrane interactions is essential to elucidate the exact working mechanism of these molecules. [1 – 4]CLPs consist of an oligopeptide chain containing both D- and L-amino acids which forms a cyclic structure by means of an ester (depsi) bond. Depending on the bacterial producer strain, there is a very large range of different CLPs that are produced. Therefore, the CLPs are classified into several groups according to oligopeptide chain length, size of the cyclic fragment and sequence similarity. CLPs adopt a well-defined amphipathic conformation, as determined by liquid-state NMR and X-ray crystallography [2, 3]. Based on a detailed analysis of individual peptide sequences, similar structural features can be found across different CLP groups. We hypothesize the existence of “super groups” with fixed structural motifs, founded on clear differences and similarities in sequence composition and length. This proposal will be discussed in the presentation by confronting the NMR-derived three-dimensional conformations of several CLPs belonging to different groups, including viscosins, orfamides, amphisins and xantholysins.These structural motifs potentially have predictive capabilities: they will allow to predict the three-dimensional structure of new CLPs and new CLP groups, or predict the effect of certain structural modification introduced by solid-phase peptide synthesis. [5] Furthermore, they can potentially be linked to a differential working mechanism across the different super groups.References1. Geudens N., M.N. Nasir, et al., Biochimica Biophysica Acta, 2017, 1859, 331-3392. Geudens N., M. De Vleeschouwer, et al., ChemBioChem, 2014, 15, 2736-27463. Sinnaeve, D., C. Michaux, et al., Tetrahedron, 2009, 65(21): 4173-41814. Sinnaeve, D., P. M. Hendrickx, et al., Chemistry - A European Journal, 2009, 15(46): 12653-126625. De Vleeschouwer, M., D. Sinnaeve, et al., Chemistry - A European Journal, 2014, 20, 7766-7775" @default.
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• W2968902133 date "2017-01-01" @default.
• W2968902133 modified "2023-10-18" @default.
• W2968902133 title "Form and function : structural variations of natural cyclic lipodepsipeptides" @default.
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