FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968908468> ?p ?o ?g. }

• W2968908468 endingPage "102314" @default.
• W2968908468 startingPage "102314" @default.
• W2968908468 abstract "The TGF-β superfamily of cytokines plays pivotal roles in the regulation of immune responses protecting against or contributing to diseases, such as, allergy, autoimmunity and cancer. Activin-A, a member of the TGF-β superfamily, was initially identified as an inducer of follicle-stimulating hormone secretion. Extensive research over the past decades illuminated fundamental roles for activin-A in essential biologic processes, including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and tissue fibrosis. Activin-A signals through two type I and two type II receptors which, upon ligand binding, activate their kinase activity, phosphorylate the SMAD2 and 3 intracellular signaling mediators that form a complex with SMAD4, translocate to the nucleus and activate or silence gene expression. Most immune cell types, including macrophages, dendritic cells (DCs), T and B lymphocytes and natural killer cells have the capacity to produce and respond to activin-A, although not in a similar manner. In innate immune cells, including macrophages, DCs and neutrophils, activin-A exerts a broad range of pro- or anti-inflammatory functions depending on the cell maturation and activation status and the spatiotemporal context. Activin-A also controls the differentiation and effector functions of Th cell subsets, including Th9 cells, TFH cells, Tr1 Treg cells and Foxp3+ Treg cells. Moreover, activin-A affects B cell responses, enhancing mucosal IgA secretion and inhibiting pathogenic autoantibody production. Interestingly, an array of preclinical and clinical studies has highlighted crucial functions of activin-A in the initiation, propagation and resolution of human diseases, including autoimmune diseases, such as, systemic lupus erythematosus, rheumatoid arthritis and pulmonary alveolar proteinosis, in allergic disorders, including allergic asthma and atopic dermatitis, in cancer and in microbial infections. Here, we provide an overview of the biology of activin-A and its signaling pathways, summarize recent studies pertinent to the role of activin-A in the modulation of inflammation and immunity, and discuss the potential of targeting activin-A as a novel therapeutic approach for the control of inflammatory diseases." @default.
• W2968908468 created "2019-08-22" @default.
• W2968908468 creator A5003221983 @default.
• W2968908468 creator A5015530538 @default.
• W2968908468 creator A5027906593 @default.
• W2968908468 creator A5078764165 @default.
• W2968908468 date "2019-11-01" @default.
• W2968908468 modified "2023-10-17" @default.
• W2968908468 title "Activin-A in the regulation of immunity in health and disease" @default.
• W2968908468 cites W1494517511 @default.
• W2968908468 cites W1532973457 @default.
• W2968908468 cites W1537444891 @default.
• W2968908468 cites W1543393238 @default.
• W2968908468 cites W1545300395 @default.
• W2968908468 cites W1546310867 @default.
• W2968908468 cites W1558667375 @default.
• W2968908468 cites W1606929570 @default.
• W2968908468 cites W1609671577 @default.
• W2968908468 cites W1632787824 @default.
• W2968908468 cites W1850152419 @default.
• W2968908468 cites W1920167267 @default.
• W2968908468 cites W1965981177 @default.
• W2968908468 cites W1966025834 @default.
• W2968908468 cites W1967805675 @default.
• W2968908468 cites W1970745879 @default.
• W2968908468 cites W1970857964 @default.
• W2968908468 cites W1971095929 @default.
• W2968908468 cites W1976928968 @default.
• W2968908468 cites W1977213877 @default.
• W2968908468 cites W1978094332 @default.
• W2968908468 cites W1982871919 @default.
• W2968908468 cites W1988913966 @default.
• W2968908468 cites W1991082974 @default.
• W2968908468 cites W1991599421 @default.
• W2968908468 cites W1995609823 @default.
• W2968908468 cites W1998719848 @default.
• W2968908468 cites W1998798750 @default.
• W2968908468 cites W1998879558 @default.
• W2968908468 cites W2002146078 @default.
• W2968908468 cites W2004298917 @default.
• W2968908468 cites W2007757724 @default.
• W2968908468 cites W2011113412 @default.
• W2968908468 cites W2016791091 @default.
• W2968908468 cites W2020139942 @default.
• W2968908468 cites W2023846059 @default.
• W2968908468 cites W2029437974 @default.
• W2968908468 cites W2030613731 @default.
• W2968908468 cites W2031724192 @default.
• W2968908468 cites W2032565220 @default.
• W2968908468 cites W2034429449 @default.
• W2968908468 cites W2034867109 @default.
• W2968908468 cites W2036561821 @default.
• W2968908468 cites W2037629418 @default.
• W2968908468 cites W2038155245 @default.
• W2968908468 cites W2039252747 @default.
• W2968908468 cites W2046505539 @default.
• W2968908468 cites W2048007521 @default.
• W2968908468 cites W2048669643 @default.
• W2968908468 cites W2048837456 @default.
• W2968908468 cites W2052704064 @default.
• W2968908468 cites W2054311195 @default.
• W2968908468 cites W2056781516 @default.
• W2968908468 cites W2058777468 @default.
• W2968908468 cites W2059183542 @default.
• W2968908468 cites W2060406004 @default.
• W2968908468 cites W2061758394 @default.
• W2968908468 cites W2067724495 @default.
• W2968908468 cites W2067935802 @default.
• W2968908468 cites W2068625824 @default.
• W2968908468 cites W2069057625 @default.
• W2968908468 cites W2069095475 @default.
• W2968908468 cites W2073748990 @default.
• W2968908468 cites W2074306506 @default.
• W2968908468 cites W2077976748 @default.
• W2968908468 cites W2079824568 @default.
• W2968908468 cites W2080831180 @default.
• W2968908468 cites W2084351152 @default.
• W2968908468 cites W2085747258 @default.
• W2968908468 cites W2089531427 @default.
• W2968908468 cites W2096059388 @default.
• W2968908468 cites W2098984609 @default.
• W2968908468 cites W2105609724 @default.
• W2968908468 cites W2108353346 @default.
• W2968908468 cites W2113253427 @default.
• W2968908468 cites W2120902187 @default.
• W2968908468 cites W2123222270 @default.
• W2968908468 cites W2127033380 @default.
• W2968908468 cites W2128100336 @default.
• W2968908468 cites W2128525445 @default.
• W2968908468 cites W2129232209 @default.
• W2968908468 cites W2130732986 @default.
• W2968908468 cites W2132666145 @default.
• W2968908468 cites W2145065299 @default.
• W2968908468 cites W2146115265 @default.
• W2968908468 cites W2146180782 @default.
• W2968908468 cites W2147101229 @default.
• W2968908468 cites W2147326531 @default.
• W2968908468 cites W2149514360 @default.

• next