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- W2968924846 abstract "5141 Based on a transcriptome database generated through the alignment of expressed sequences tags (ESTs) to the human genome sequence, we developed a transcript finishing strategy for the characterization of new human genes1. Using this strategy we identified a transcript cluster composed of ESTs derived from normal testis and tumor tissues. This suited the expression pattern observed for a category of tumor antigens: the cancer-testis (CT) antigens. These antigens are considered promising candidates for cancer immunotherapy and the identification of new CT antigens is essential for the development of polyvalent vaccines designed to overcome tumor heterogeneity and antigen loss. The restricted expression pattern of the new transcript was confirmed by RT-PCR using cDNA panels derived from 21 normal tissues and 21 tumor cell lines as well as from tumor samples derived from 15 different types of tumors. Among the 177 tumor samples analyzed, 41% expressed our transcript. The complete sequence of this new transcript, now named SPCT-1, was generated and mapped to chromosome 21. The transcript has 3916bp, distributed over 15 exons and presents several alternative splicing isoforms. The presence of anti-SPCT1 antibodies was examined by Western blot in sera derived from cancer patients and normal individuals. Anti-SPCT1 antibodies were exclusively detected in sera derived from cancer patients (20% of the 148 sera analysed so far). Immunohistochemical analysis for SPCT-1 using a specific polyclonal antibody revealed a strong staining in spermatogonias and in tumor cells. Taken together, these results show that SPCT-1 is a new member of the CT-antigen family with tumor-testis specific expression and high immunogenicity in cancer patients. 1-Ludwig-FAPESP Transcript Finishing Initiative. Genome Res. 2004 Jul;14(7):1413-23" @default.
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- W2968924846 date "2005-05-01" @default.
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- W2968924846 title "Identification and characterization of a new tumor antigen: SPCT-1" @default.
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