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- W2968925362 endingPage "108071" @default.
- W2968925362 startingPage "108071" @default.
- W2968925362 abstract "Heme and iron are essential to almost all forms of life. The strict maintenance of heme and iron homeostasis is essential to prevent cellular toxicity and the existence of systemic and intracellular regulation is fundamental. Cytosolic heme can be catabolized and detoxified by heme oxygenases (HOs). Interestingly, free heme detoxification through HOs results in the production of free ferrous iron, which can be potentially hazardous for cells. Recently, the intracellular iron chaperone, poly (rC)-binding protein 2 (PCBP2), has been identified, which can be involved in accepting iron after heme catabolism as well as intracellular iron transport. In fact, HO1, NADPH-cytochrome P450 reductase, and PCBP2 form a functional unit that integrates the catabolism of heme with the binding and transport of iron by PCBP2. In this review, we provide an overview of our understanding of the iron chaperones and discuss the mechanism how iron chaperones bind iron released during the process of heme degradation." @default.
- W2968925362 created "2019-08-22" @default.
- W2968925362 creator A5017905338 @default.
- W2968925362 creator A5055725109 @default.
- W2968925362 creator A5069594191 @default.
- W2968925362 creator A5090966781 @default.
- W2968925362 date "2019-09-01" @default.
- W2968925362 modified "2023-10-17" @default.
- W2968925362 title "How iron is handled in the course of heme catabolism: Integration of heme oxygenase with intracellular iron transport mechanisms mediated by poly (rC)-binding protein-2" @default.
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