Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968994417> ?p ?o ?g. }
- W2968994417 abstract "ABSTRACT Synapses are largely established during embryogenesis and maintained during growth. The mechanisms that regulate synaptic allometry—the maintenance of synaptic positions during growth—are largely unknown. We performed forward genetic screens in C. elegans for synaptic allometry mutants and identified mig-17 , a secreted metalloprotease of the conserved ADAMTS family. Through proteomic mass spectrometry analyses, cell biological and genetic studies we determined that MIG-17 is expressed by muscle cells to modulate glia location and morphology. Glia are proximal to synapses, and the glial location and morphology determine synaptic position during growth. Mig-17 regulates synapse allometry by influencing epidermal-glia crosstalk through the regulation of basement membrane proteins, including collagen type IV, SPARC and fibulin. Our findings underscore the importance of glia location in the maintenance of synaptic allometry, and uncover a muscle-epidermal-glia signaling axis, mediated through the extracellular matrix, in the regulation of glia morphology and synaptic positions during growth." @default.
- W2968994417 created "2019-08-22" @default.
- W2968994417 creator A5011065681 @default.
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- W2968994417 creator A5081545474 @default.
- W2968994417 date "2019-08-16" @default.
- W2968994417 modified "2023-10-12" @default.
- W2968994417 title "ADAMTS-family protease MIG-17 regulates synaptic allometry by modifying the extracellular matrix and modulating glia morphology during growth" @default.
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