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• W2968994715 abstract "Abstract Aim Efficacy of platinum based‐chemotherapy is limited by cisplatin (DDP) resistance, however, the underlying mechanism of cisplatin resistance remains unclear. We aimed to investigate the role of miR‐1271 in cisplatin‐resistant ovarian cancer cells. Methods Transfection of miR‐1271 mimic and inhibitor was performed to study the role of miR‐1271 in ovarian cancer. Cell viability was assessed by Cell Counting Kit (CCK)‐8 assay. Flow cytometry was used to determine the apoptosis rates. Quantitative reverse transcription polymerase chain reaction (qRT‐PCR) and Western blot were used to detect mRNA and protein expressions. Target predicted by Targetscan7.2 was confirmed by dual‐luciferase activity assay. Mammalian target of rapamycin (mTOR) siRNA (simTOR) co‐transfection was performed to verify the role of mTOR in the suppression effect of miR‐1271 on ovarian cancer. Results In SKOV3 cells, miR‐1271 overexpression significantly decreased cell viability and up‐regulated apoptosis rate (from 5.54% of control to 24.03%). MiR‐1271 adversely affected SKOV3 cell migration and invasion, and induced the upregulation of E‐cadherin and downregulation of N‐cadherin and alpha‐smooth muscle actin (α‐SMA). Moreover, SKOV3/DDP cells had a lower miR‐1271 level, and enhancing miR‐1271 contributed strongly to cisplatin‐induced apoptosis through altering the expressions of B‐cell lymphoma‐2 associated X protein (BAX), cleaved caspase‐3 and B‐cell lymphoma 2 (Bcl‐2). In contrast, the opposite result was observed in miR‐1271 inhibitor. mTOR was identified to be a target of miR‐1271. SimTOR partially reversed the increased cell viability under the effect of miR‐1271 inhibitor. Conclusion Our data indicate that miR‐1271 can inhibit the ovarian cancer epithelial‐mesenchymal transition (EMT) and sensitize resistant cells to cisplatin‐induced apoptosis through blocking mTOR expression." @default.
• W2968994715 created "2019-08-22" @default.
• W2968994715 creator A5012278873 @default.
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• W2968994715 date "2019-08-14" @default.
• W2968994715 modified "2023-09-24" @default.
• W2968994715 title "Effects of microRNA‐1271 on ovarian cancer via inhibition of epithelial‐mesenchymal transition and cisplatin resistance" @default.
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• W2968994715 doi "https://doi.org/10.1111/jog.14079" @default.
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