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• W2969026360 abstract "<ns3:p><ns3:bold>Background: </ns3:bold>Agitated and aggressive behaviours are common in the psychiatric setting and rapid tranquilisation is sometimes unavoidable. A survey of Lebanese practice has shown that an intramuscular haloperidol, promethazine and chlorpromazine combination is a preferred form of treatment but there are no randomised trials of this triple therapy.</ns3:p><ns3:p> <ns3:bold>Methods:</ns3:bold> This is a pragmatic randomised trial. Setting - the psychiatric wards of the Psychiatric Hospital of the Cross, Jal Eddib, Lebanon. Participants - any adult patient in the hospital who displays an aggressive episode for whom rapid tranquilisation is unavoidable, who has not been randomised before, for whom there are no known contraindications. Randomisation – stratified (by ward) randomisation and concealed in closed opaque envelope by independent parties. Procedure – if the clinical situation arises requiring rapid tranquilisation, medical residents overseeing the patient will open a TREC-Lebanon envelope in which will be notification of which group of treatments should be preferred [Haloperidol + Promethazine + Chlorpromazine (HPC) or Haloperidol + Promethazine (HP)], along with forms for primary, secondary and serious adverse effects. Treatment is not given blindly. Outcome - primary outcome is calm or tranquil at 20 minutes post intervention. Secondary outcomes are calm/tranquil at 40, 60 and 120 minutes post intervention, asleep, adverse effects, use of straitjacket and leaving the ward. Follow-up will be up to two weeks post randomisation.</ns3:p><ns3:p> <ns3:bold>Discussion: </ns3:bold>Findings from this study will compare the HPC versus HP combination used in Lebanon’s psychiatry emergency routine practice.</ns3:p><ns3:p> <ns3:bold>Trial registration: </ns3:bold>ClinicalTrials.gov <ns3:ext-link xmlns:ns4=http://www.w3.org/1999/xlink ext-link-type=uri ns4:href=https://clinicaltrials.gov/ct2/show/NCT03639558>NCT03639558</ns3:ext-link>. Registration date, August 21, 2018.</ns3:p>" @default.
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• W2969026360 date "2019-08-15" @default.
• W2969026360 modified "2023-09-23" @default.
• W2969026360 title "Study protocol for a randomised controlled trial of haloperidol plus promethazine plus chlorpromazine versus haloperidol plus promethazine for rapid tranquilisation for agitated psychiatric patients in the emergency setting (TREC-Lebanon)" @default.
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• W2969026360 doi "https://doi.org/10.12688/f1000research.19933.1" @default.
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