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- W2969044846 abstract "Pulmonary arterial hypertension (PAH) is characterized by progressive pulmonary artery remodelling leading to increased right ventricular pressure overload, which results in right heart failure and premature death. Inflammation plays a central role in the development of PAH, and the recruitment and function of immune cells are tightly regulated by chemotactic cytokines called chemokines. A number of studies have shown that the development and progression of PAH are associated with the dysregulated expression of several chemokines and chemokine receptors in the pulmonary vasculature. Moreover, some chemokines are differentially regulated in the pressure‐overloaded right ventricle. Recent studies have tested the efficacy of pharmacological agents targeting several chemokines and chemokine receptors for their effects on the development of PAH, suggesting that these receptors could serve as useful therapeutic targets. In this review, we provide recent insights into the role of chemokines and chemokine receptors in PAH and RV remodelling and the opportunities and roadblocks in targeting them. LINKED ARTICLES This article is part of a themed issue on Risk factors, comorbidities, and comedications in cardioprotection. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.1/issuetoc" @default.
- W2969044846 created "2019-08-22" @default.
- W2969044846 creator A5027784658 @default.
- W2969044846 creator A5042853896 @default.
- W2969044846 creator A5043857150 @default.
- W2969044846 creator A5072984121 @default.
- W2969044846 creator A5081385074 @default.
- W2969044846 date "2019-11-03" @default.
- W2969044846 modified "2023-10-18" @default.
- W2969044846 title "The role of chemokines and chemokine receptors in pulmonary arterial hypertension" @default.
- W2969044846 cites W1574845707 @default.
- W2969044846 cites W1758075256 @default.
- W2969044846 cites W1806230168 @default.
- W2969044846 cites W1837906093 @default.
- W2969044846 cites W1915697415 @default.
- W2969044846 cites W1932584694 @default.
- W2969044846 cites W1966268633 @default.
- W2969044846 cites W1968742688 @default.
- W2969044846 cites W1969554913 @default.
- W2969044846 cites W1980173416 @default.
- W2969044846 cites W1981694028 @default.
- W2969044846 cites W1987058361 @default.
- W2969044846 cites W1987223361 @default.
- W2969044846 cites W1987602196 @default.
- W2969044846 cites W1988168296 @default.
- W2969044846 cites W1994378425 @default.
- W2969044846 cites W1994387916 @default.
- W2969044846 cites W1995186495 @default.
- W2969044846 cites W1995581477 @default.
- W2969044846 cites W2000314052 @default.
- W2969044846 cites W2002925464 @default.
- W2969044846 cites W2004356125 @default.
- W2969044846 cites W2006232527 @default.
- W2969044846 cites W2011477996 @default.
- W2969044846 cites W2014596880 @default.
- W2969044846 cites W2014944795 @default.
- W2969044846 cites W2018848310 @default.
- W2969044846 cites W2020050440 @default.
- W2969044846 cites W2022247298 @default.
- W2969044846 cites W2025930905 @default.
- W2969044846 cites W2028884555 @default.
- W2969044846 cites W2032142079 @default.
- W2969044846 cites W2032402428 @default.
- W2969044846 cites W2041595354 @default.
- W2969044846 cites W2041913558 @default.
- W2969044846 cites W2049404716 @default.
- W2969044846 cites W2054627346 @default.
- W2969044846 cites W2054666491 @default.
- W2969044846 cites W2055115766 @default.
- W2969044846 cites W2059591371 @default.
- W2969044846 cites W2065114932 @default.
- W2969044846 cites W2067633795 @default.
- W2969044846 cites W2068366232 @default.
- W2969044846 cites W2075833457 @default.
- W2969044846 cites W2080485237 @default.
- W2969044846 cites W2080996739 @default.
- W2969044846 cites W2083046667 @default.
- W2969044846 cites W2084122961 @default.
- W2969044846 cites W2084853567 @default.
- W2969044846 cites W2085262797 @default.
- W2969044846 cites W2085898726 @default.
- W2969044846 cites W2088465910 @default.
- W2969044846 cites W2088605349 @default.
- W2969044846 cites W2096510242 @default.
- W2969044846 cites W2098586887 @default.
- W2969044846 cites W2100020795 @default.
- W2969044846 cites W2107640422 @default.
- W2969044846 cites W2108707328 @default.
- W2969044846 cites W2110051509 @default.
- W2969044846 cites W2111142085 @default.
- W2969044846 cites W2112150364 @default.
- W2969044846 cites W2112918183 @default.
- W2969044846 cites W2113359020 @default.
- W2969044846 cites W2120187885 @default.
- W2969044846 cites W2122792864 @default.
- W2969044846 cites W2126972955 @default.
- W2969044846 cites W2129104904 @default.
- W2969044846 cites W2129211024 @default.
- W2969044846 cites W2131601314 @default.
- W2969044846 cites W2134644007 @default.
- W2969044846 cites W2135865566 @default.
- W2969044846 cites W2140348032 @default.
- W2969044846 cites W2140487504 @default.
- W2969044846 cites W2143134153 @default.
- W2969044846 cites W2143318553 @default.
- W2969044846 cites W2144065069 @default.
- W2969044846 cites W2144476786 @default.
- W2969044846 cites W2145738273 @default.
- W2969044846 cites W2149121265 @default.
- W2969044846 cites W2153423299 @default.
- W2969044846 cites W2154351936 @default.
- W2969044846 cites W2155013589 @default.
- W2969044846 cites W2155295345 @default.
- W2969044846 cites W2156343903 @default.
- W2969044846 cites W2161370807 @default.
- W2969044846 cites W2162698108 @default.
- W2969044846 cites W2163513913 @default.
- W2969044846 cites W2164204972 @default.