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- W2969052014 endingPage "11176" @default.
- W2969052014 startingPage "11170" @default.
- W2969052014 abstract "We have developed a conjugation reaction based on the thia-Michael addition to activated triple bonds, which can be an alternative to maleimides, the most commonly used reagents to link thiol groups (of Cys) to drugs and labels. An amino group is converted into its propynamide and, in aqueous media at 37 °C and pH 7.4, Cys derivatives are added. The oxopropene-1,3-diyl linker is formed with excellent Z selectivity without secondary reactions. No exchange with other thiols is observed." @default.
- W2969052014 created "2019-08-22" @default.
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- W2969052014 date "2019-08-14" @default.
- W2969052014 modified "2023-09-27" @default.
- W2969052014 title "(<i>Z</i>)-Oxopropene-1,3-diyl, a Linker for the Conjugation of the Thiol Group of Cysteine with Amino-Derivatized Drugs" @default.
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- W2969052014 doi "https://doi.org/10.1021/acs.joc.8b02686" @default.
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- W2969052014 hasPublicationYear "2019" @default.
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