FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969068760> ?p ?o ?g. }

• W2969068760 endingPage "L549" @default.
• W2969068760 startingPage "L539" @default.
• W2969068760 abstract "Surfactant protein-D (SP-D) is a regulator of pulmonary innate immunity whose oligomeric state can be altered through S-nitrosylation to regulate its signaling function in macrophages. Here, we examined how nitrosylation of SP-D alters the phenotypic response of macrophages to stimuli both in vivo and in vitro. Bronchoalveolar lavage (BAL) from C57BL6/J and SP-D-overexpressing (SP-D OE) mice was incubated with RAW264.7 cells ± LPS. LPS induces the expression of the inflammatory genes Il1b and Nos2, which is reduced 10-fold by SP-D OE-BAL. S-nitrosylation of the SP-D OE-BAL (SNO-SP-D OE-BAL) abrogated this inhibition. SNO-SP-D OE-BAL alone induced Il1b and Nos2 expression. PCR array analysis of macrophages incubated with SP-D OE-BAL (±LPS) shows increased expression of repair genes, Ccl20, Cxcl1, and Vcam1, that was accentuated by LPS. LPS increases inflammatory gene expression, Il1a, Nos2, Tnf, and Ptgs2, which was accentuated by SNO-SP-D OE-BAL but inhibited by SP-D OE-BAL. The transcription factor NF-κB was identified as a target for SNO-SP-D by IPA, which was confirmed by Trans-AM ELISA in vitro. In vivo, SP-D overexpression increases the burden of infection in a Pneumocystis model while increasing cellular recruitment. Expression of iNOS and the production of NO metabolites were significantly reduced in SP-D OE mice relative to C57BL6/J. Inflammatory gene expression was increased in infected C57BL6/J mice but decreased in SP-D OE. SP-D oligomeric structure was disrupted in C57BL6/J infected mice but unaltered within SP-D OE. Thus SP-D modulates macrophage phenotype and the balance of multimeric to trimeric SP-D is critical to this regulation." @default.
• W2969068760 created "2019-08-22" @default.
• W2969068760 creator A5021760409 @default.
• W2969068760 creator A5026186455 @default.
• W2969068760 creator A5040346803 @default.
• W2969068760 creator A5040694955 @default.
• W2969068760 creator A5056068190 @default.
• W2969068760 creator A5063986129 @default.
• W2969068760 date "2019-11-01" @default.
• W2969068760 modified "2023-10-18" @default.
• W2969068760 title "Surfactant protein-D modulation of pulmonary macrophage phenotype is controlled byS-nitrosylation" @default.
• W2969068760 cites W1543504325 @default.
• W2969068760 cites W1578182072 @default.
• W2969068760 cites W1962869168 @default.
• W2969068760 cites W1977843596 @default.
• W2969068760 cites W1979019728 @default.
• W2969068760 cites W1983220630 @default.
• W2969068760 cites W2007087386 @default.
• W2969068760 cites W2008308371 @default.
• W2969068760 cites W2017915940 @default.
• W2969068760 cites W2018404794 @default.
• W2969068760 cites W2020012047 @default.
• W2969068760 cites W2020213576 @default.
• W2969068760 cites W2020317305 @default.
• W2969068760 cites W2020744745 @default.
• W2969068760 cites W2021707617 @default.
• W2969068760 cites W2032532790 @default.
• W2969068760 cites W2053891616 @default.
• W2969068760 cites W2054472394 @default.
• W2969068760 cites W2056109605 @default.
• W2969068760 cites W2078356191 @default.
• W2969068760 cites W2084443730 @default.
• W2969068760 cites W2084868809 @default.
• W2969068760 cites W2101032508 @default.
• W2969068760 cites W2111550054 @default.
• W2969068760 cites W2118694988 @default.
• W2969068760 cites W2140807512 @default.
• W2969068760 cites W2145082642 @default.
• W2969068760 cites W2145106662 @default.
• W2969068760 cites W2147002444 @default.
• W2969068760 cites W2152127772 @default.
• W2969068760 cites W2155579325 @default.
• W2969068760 cites W2158022781 @default.
• W2969068760 cites W2161157806 @default.
• W2969068760 cites W2162143298 @default.
• W2969068760 cites W2165365415 @default.
• W2969068760 cites W2165892104 @default.
• W2969068760 cites W2168203604 @default.
• W2969068760 cites W2191792742 @default.
• W2969068760 cites W2224453591 @default.
• W2969068760 cites W2292593691 @default.
• W2969068760 cites W2303753707 @default.
• W2969068760 cites W2747213366 @default.
• W2969068760 cites W2761725839 @default.
• W2969068760 cites W2768029258 @default.
• W2969068760 cites W2770221822 @default.
• W2969068760 cites W278687238 @default.
• W2969068760 cites W2791220190 @default.
• W2969068760 cites W2792748704 @default.
• W2969068760 cites W2811175620 @default.
• W2969068760 doi "https://doi.org/10.1152/ajplung.00506.2018" @default.
• W2969068760 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6957369" @default.
• W2969068760 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31411060" @default.
• W2969068760 hasPublicationYear "2019" @default.
• W2969068760 type Work @default.
• W2969068760 sameAs 2969068760 @default.
• W2969068760 citedByCount "8" @default.
• W2969068760 countsByYear W29690687602019 @default.
• W2969068760 countsByYear W29690687602020 @default.
• W2969068760 countsByYear W29690687602021 @default.
• W2969068760 countsByYear W29690687602023 @default.
• W2969068760 crossrefType "journal-article" @default.
• W2969068760 hasAuthorship W2969068760A5021760409 @default.
• W2969068760 hasAuthorship W2969068760A5026186455 @default.
• W2969068760 hasAuthorship W2969068760A5040346803 @default.
• W2969068760 hasAuthorship W2969068760A5040694955 @default.
• W2969068760 hasAuthorship W2969068760A5056068190 @default.
• W2969068760 hasAuthorship W2969068760A5063986129 @default.
• W2969068760 hasBestOaLocation W29690687601 @default.
• W2969068760 hasConcept C104317684 @default.
• W2969068760 hasConcept C126322002 @default.
• W2969068760 hasConcept C133493029 @default.
• W2969068760 hasConcept C13373296 @default.
• W2969068760 hasConcept C136449434 @default.
• W2969068760 hasConcept C150194340 @default.
• W2969068760 hasConcept C150903083 @default.
• W2969068760 hasConcept C153911025 @default.
• W2969068760 hasConcept C17991360 @default.
• W2969068760 hasConcept C185592680 @default.
• W2969068760 hasConcept C194108754 @default.
• W2969068760 hasConcept C202751555 @default.
• W2969068760 hasConcept C203014093 @default.
• W2969068760 hasConcept C207001950 @default.
• W2969068760 hasConcept C2776914184 @default.
• W2969068760 hasConcept C2777438239 @default.
• W2969068760 hasConcept C2777714996 @default.
• W2969068760 hasConcept C2777961210 @default.
• W2969068760 hasConcept C2778012055 @default.

• next