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- W2969084200 endingPage "1155" @default.
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- W2969084200 abstract "Flipping a lipid The membranes of eukaryotic cells have different lipid compositions in their inner and outer leaflets. Enzymes known as flippases and floppases use the energy from adenosine triphosphate (ATP) hydrolysis to translocate lipids against a concentration gradient from the outer to inner or inner to outer leaflets, respectively. Flippases are P4-type ATPases that are important in processes such as membrane trafficking, signaling, and apoptosis. Hiraizumi et al. report the cryo–electron microscopy structure of six intermediates of the human flippase ATP8A1 bound to the partner protein it requires for function, CDC50. ATP binding and autophosphorylation of ATP8A1 drive a cycle of conformations in which lipids bind differently, powering translocation. Science , this issue p. 1149" @default.
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- W2969084200 date "2019-09-13" @default.
- W2969084200 modified "2023-10-10" @default.
- W2969084200 title "Cryo-EM structures capture the transport cycle of the P4-ATPase flippase" @default.
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- W2969084200 doi "https://doi.org/10.1126/science.aay3353" @default.
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