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• W2969093022 endingPage "871" @default.
• W2969093022 startingPage "871" @default.
• W2969093022 abstract "Patients with long-term, treated, rheumatoid arthritis (RA) show abnormalities in their circulating CD4+ T-lymphocytes, but whether this occurs in recently diagnosed naïve patients to disease-modifying drugs (DMARDs) is under discussion. These patients show heterogeneous clinical response to methotrexate (MTX) treatment. We have examined the count of circulating CD4+ T-lymphocytes, and their naïve (TN), central memory (TCM), effector memory (TEM) and effector (TE) subsets, CD28 expression and Vβ TCR repertoire distribution by polychromatic flow cytometry in a population of 68 DMARD-naïve recently diagnosed RA patients, before and after 3 and 6 months of MTX treatment. At pre-treatment baseline, patients showed an expansion of the counts of CD4+ TN, TEM, TE and TCM lymphocyte subsets, and of total CD4+CD28− cells and of the TE subset with a different pattern of numbers in MTX responder and non-responders. The expansion of CD4+TEM lymphocytes showed a predictive value of MTX non-response. MTX treatment was associated to different modifications in the counts of the CD4+ subsets and of the Vβ TCR repertoire family distribution and in the level of CD28 expression in responders and non-responders. In conclusion, the disturbance of CD4+ lymphocytes is already found in DMARD-naïve RA patients with different patterns of alterations in MTX responders and non-responders." @default.
• W2969093022 created "2019-08-22" @default.
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• W2969093022 date "2019-08-10" @default.
• W2969093022 modified "2023-10-16" @default.
• W2969093022 title "The Abnormal CD4+T Lymphocyte Subset Distribution and Vbeta Repertoire in New-onset Rheumatoid Arthritis Can Be Modulated by Methotrexate Treament" @default.
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• W2969093022 doi "https://doi.org/10.3390/cells8080871" @default.
• W2969093022 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6721760" @default.
• W2969093022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31405169" @default.
• W2969093022 hasPublicationYear "2019" @default.
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