FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969094590> ?p ?o ?g. }

• W2969094590 endingPage "9479" @default.
• W2969094590 startingPage "9467" @default.
• W2969094590 abstract "Abstract The DNA damage response (DDR) encompasses the cellular response to DNA double-stranded breaks (DSBs), and includes recognition of the DSB, recruitment of numerous factors to the DNA damage site, initiation of signaling cascades, chromatin remodeling, cell-cycle checkpoint activation, and repair of the DSB. Key drivers of the DDR are multiple members of the phosphatidylinositol 3-kinase-related kinase family, including ataxia telangiectasia mutated (ATM), ataxia telangiectasia and Rad3-related (ATR), and the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). ATM and ATR modulate multiple portions of the DDR, but DNA-PKcs is believed to primarily function in the DSB repair pathway, non-homologous end joining. Utilizing a human cell line in which the kinase domain of DNA-PKcs is inactivated, we show here that DNA-PKcs kinase activity is required for the cellular response to DSBs immediately after their induction. Specifically, DNA-PKcs kinase activity initiates phosphorylation of the chromatin factors H2AX and KAP1 following ionizing radiation exposure and drives local chromatin decondensation near the DSB site. Furthermore, loss of DNA-PKcs kinase activity results in a marked decrease in the recruitment of numerous members of the DDR machinery to DSBs. Collectively, these results provide clear evidence that DNA-PKcs activity is pivotal for the initiation of the DDR." @default.
• W2969094590 created "2019-08-22" @default.
• W2969094590 creator A5023086146 @default.
• W2969094590 creator A5047024745 @default.
• W2969094590 creator A5056439897 @default.
• W2969094590 creator A5066373462 @default.
• W2969094590 creator A5081758694 @default.
• W2969094590 date "2019-08-09" @default.
• W2969094590 modified "2023-10-17" @default.
• W2969094590 title "DNA-PKcs promotes chromatin decondensation to facilitate initiation of the DNA damage response" @default.
• W2969094590 cites W1964495746 @default.
• W2969094590 cites W1969503475 @default.
• W2969094590 cites W1970827792 @default.
• W2969094590 cites W1972509315 @default.
• W2969094590 cites W1973874596 @default.
• W2969094590 cites W1976336745 @default.
• W2969094590 cites W1978727038 @default.
• W2969094590 cites W1985775217 @default.
• W2969094590 cites W1999012527 @default.
• W2969094590 cites W2010901031 @default.
• W2969094590 cites W2013898632 @default.
• W2969094590 cites W2020825769 @default.
• W2969094590 cites W2023620387 @default.
• W2969094590 cites W2030763718 @default.
• W2969094590 cites W2031203839 @default.
• W2969094590 cites W2032348296 @default.
• W2969094590 cites W2034582922 @default.
• W2969094590 cites W2036749550 @default.
• W2969094590 cites W2067228541 @default.
• W2969094590 cites W2068668324 @default.
• W2969094590 cites W2069741865 @default.
• W2969094590 cites W2071457560 @default.
• W2969094590 cites W2076561725 @default.
• W2969094590 cites W2077436902 @default.
• W2969094590 cites W2086897927 @default.
• W2969094590 cites W2103770333 @default.
• W2969094590 cites W2110177038 @default.
• W2969094590 cites W2110817748 @default.
• W2969094590 cites W2111420919 @default.
• W2969094590 cites W2112651502 @default.
• W2969094590 cites W2113780833 @default.
• W2969094590 cites W2124036399 @default.
• W2969094590 cites W2132396299 @default.
• W2969094590 cites W2141575449 @default.
• W2969094590 cites W2142757721 @default.
• W2969094590 cites W2143629217 @default.
• W2969094590 cites W2144386367 @default.
• W2969094590 cites W2144512576 @default.
• W2969094590 cites W2144793302 @default.
• W2969094590 cites W2145200068 @default.
• W2969094590 cites W2151252396 @default.
• W2969094590 cites W2164362605 @default.
• W2969094590 cites W2166826534 @default.
• W2969094590 cites W2168728703 @default.
• W2969094590 cites W2226122803 @default.
• W2969094590 cites W2587610309 @default.
• W2969094590 cites W2625452721 @default.
• W2969094590 cites W2769114963 @default.
• W2969094590 cites W2773508959 @default.
• W2969094590 cites W2792729825 @default.
• W2969094590 doi "https://doi.org/10.1093/nar/gkz694" @default.
• W2969094590 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6765147" @default.
• W2969094590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31396623" @default.
• W2969094590 hasPublicationYear "2019" @default.
• W2969094590 type Work @default.
• W2969094590 sameAs 2969094590 @default.
• W2969094590 citedByCount "48" @default.
• W2969094590 countsByYear W29690945902020 @default.
• W2969094590 countsByYear W29690945902021 @default.
• W2969094590 countsByYear W29690945902022 @default.
• W2969094590 countsByYear W29690945902023 @default.
• W2969094590 crossrefType "journal-article" @default.
• W2969094590 hasAuthorship W2969094590A5023086146 @default.
• W2969094590 hasAuthorship W2969094590A5047024745 @default.
• W2969094590 hasAuthorship W2969094590A5056439897 @default.
• W2969094590 hasAuthorship W2969094590A5066373462 @default.
• W2969094590 hasAuthorship W2969094590A5081758694 @default.
• W2969094590 hasBestOaLocation W29690945901 @default.
• W2969094590 hasConcept C134935766 @default.
• W2969094590 hasConcept C143425029 @default.
• W2969094590 hasConcept C153911025 @default.
• W2969094590 hasConcept C167227067 @default.
• W2969094590 hasConcept C184235292 @default.
• W2969094590 hasConcept C54355233 @default.
• W2969094590 hasConcept C552990157 @default.
• W2969094590 hasConcept C68748289 @default.
• W2969094590 hasConcept C83640560 @default.
• W2969094590 hasConcept C86803240 @default.
• W2969094590 hasConcept C95444343 @default.
• W2969094590 hasConcept C97029542 @default.
• W2969094590 hasConceptScore W2969094590C134935766 @default.
• W2969094590 hasConceptScore W2969094590C143425029 @default.
• W2969094590 hasConceptScore W2969094590C153911025 @default.
• W2969094590 hasConceptScore W2969094590C167227067 @default.
• W2969094590 hasConceptScore W2969094590C184235292 @default.
• W2969094590 hasConceptScore W2969094590C54355233 @default.
• W2969094590 hasConceptScore W2969094590C552990157 @default.
• W2969094590 hasConceptScore W2969094590C68748289 @default.

• next