Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969128265> ?p ?o ?g. }
- W2969128265 abstract "We introduce and analyze a mathematical model for the regeneration of planarian flatworms. This system of differential equations incorporates dynamics of head and tail cells which express positional control genes that in turn translate into localized signals that guide stem cell differentiation. Orientation and positional information is encoded in the dynamics of a long range wnt-related signaling gradient. We motivate our model in relation to experimental data and demonstrate how it correctly reproduces cut and graft experiments. In particular, our system improves on previous models by preserving polarity in regeneration, over orders of magnitude in body size during cutting experiments and growth phases. Our model relies on tristability in cell density dynamics, between head, trunk, and tail. In addition, key to polarity preservation in regeneration, our system includes sensitivity of cell differentiation to gradients of wnt-related signals %measured relative to the tissue surface. This process is particularly relevant in a small tissue layer close to wounds during their healing, and modeled here in a robust fashion through dynamic boundary conditions." @default.
- W2969128265 created "2019-08-22" @default.
- W2969128265 creator A5033830372 @default.
- W2969128265 creator A5059535856 @default.
- W2969128265 creator A5065276682 @default.
- W2969128265 date "2019-08-12" @default.
- W2969128265 modified "2023-09-27" @default.
- W2969128265 title "Signaling gradients in surface dynamics as basis for planarian regeneration" @default.
- W2969128265 cites W1201628459 @default.
- W2969128265 cites W1578108799 @default.
- W2969128265 cites W1660042663 @default.
- W2969128265 cites W1784854092 @default.
- W2969128265 cites W1851513701 @default.
- W2969128265 cites W1932552719 @default.
- W2969128265 cites W1970613379 @default.
- W2969128265 cites W1974276287 @default.
- W2969128265 cites W1980661496 @default.
- W2969128265 cites W1981287744 @default.
- W2969128265 cites W1985251822 @default.
- W2969128265 cites W1986652156 @default.
- W2969128265 cites W1987393138 @default.
- W2969128265 cites W1989512459 @default.
- W2969128265 cites W1990771698 @default.
- W2969128265 cites W1995483818 @default.
- W2969128265 cites W1997389247 @default.
- W2969128265 cites W1997784755 @default.
- W2969128265 cites W1998131012 @default.
- W2969128265 cites W2000572318 @default.
- W2969128265 cites W2005646444 @default.
- W2969128265 cites W2006566159 @default.
- W2969128265 cites W2011040505 @default.
- W2969128265 cites W2015621557 @default.
- W2969128265 cites W2016350172 @default.
- W2969128265 cites W2017754446 @default.
- W2969128265 cites W2023265934 @default.
- W2969128265 cites W2024160845 @default.
- W2969128265 cites W2026083956 @default.
- W2969128265 cites W2026641296 @default.
- W2969128265 cites W2030473251 @default.
- W2969128265 cites W2035836174 @default.
- W2969128265 cites W2037793987 @default.
- W2969128265 cites W2037798895 @default.
- W2969128265 cites W2040723453 @default.
- W2969128265 cites W2048712299 @default.
- W2969128265 cites W2055082496 @default.
- W2969128265 cites W2056965916 @default.
- W2969128265 cites W2066972948 @default.
- W2969128265 cites W2067123657 @default.
- W2969128265 cites W2088692961 @default.
- W2969128265 cites W2089840306 @default.
- W2969128265 cites W2102647227 @default.
- W2969128265 cites W2106740149 @default.
- W2969128265 cites W2119455906 @default.
- W2969128265 cites W2122973664 @default.
- W2969128265 cites W2132982902 @default.
- W2969128265 cites W2136653559 @default.
- W2969128265 cites W2138336686 @default.
- W2969128265 cites W2142528855 @default.
- W2969128265 cites W2142801207 @default.
- W2969128265 cites W2144375779 @default.
- W2969128265 cites W2154307309 @default.
- W2969128265 cites W2160875943 @default.
- W2969128265 cites W2162689493 @default.
- W2969128265 cites W2168153553 @default.
- W2969128265 cites W2168257801 @default.
- W2969128265 cites W2191053757 @default.
- W2969128265 cites W2274021321 @default.
- W2969128265 cites W2332536468 @default.
- W2969128265 cites W2343860250 @default.
- W2969128265 cites W2443634204 @default.
- W2969128265 cites W2527534872 @default.
- W2969128265 cites W2530724672 @default.
- W2969128265 cites W2587163858 @default.
- W2969128265 cites W2736447405 @default.
- W2969128265 cites W2884417786 @default.
- W2969128265 cites W2890039560 @default.
- W2969128265 cites W2913278615 @default.
- W2969128265 cites W2952266927 @default.
- W2969128265 cites W2962770433 @default.
- W2969128265 cites W2963666664 @default.
- W2969128265 cites W2964008828 @default.
- W2969128265 cites W2964154295 @default.
- W2969128265 cites W3008308691 @default.
- W2969128265 cites W3102086366 @default.
- W2969128265 cites W3104082195 @default.
- W2969128265 cites W92794652 @default.
- W2969128265 cites W3203680921 @default.
- W2969128265 hasPublicationYear "2019" @default.
- W2969128265 type Work @default.
- W2969128265 sameAs 2969128265 @default.
- W2969128265 citedByCount "0" @default.
- W2969128265 crossrefType "posted-content" @default.
- W2969128265 hasAuthorship W2969128265A5033830372 @default.
- W2969128265 hasAuthorship W2969128265A5059535856 @default.
- W2969128265 hasAuthorship W2969128265A5065276682 @default.
- W2969128265 hasConcept C111919701 @default.
- W2969128265 hasConcept C121332964 @default.
- W2969128265 hasConcept C137620995 @default.
- W2969128265 hasConcept C145912823 @default.
- W2969128265 hasConcept C1491633281 @default.