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- W2969156734 endingPage "e750" @default.
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- W2969156734 abstract "Abstract Arterial spin labeling (ASL) is a perfusion-based functional magnetic resonance imaging technique that uses water in arterial blood as a freely diffusible tracer to measure regional cerebral blood flow noninvasively. To date, its application to the study of pain has been relatively limited. Yet, ASL possesses key features that make it uniquely positioned to study pain in certain paradigms. For instance, ASL is sensitive to very slowly fluctuating brain signals (in the order of minutes or longer). This characteristic makes ASL particularly suitable for the evaluation of brain mechanisms of tonic experimental, postsurgical, and ongoing/or continuously varying pain in chronic or acute pain conditions (whereas blood-oxygen level–dependent functional magnetic resonance is better suited to detect brain responses to short-lasting or phasic/evoked pain). Unlike positron emission tomography or other perfusion techniques, ASL allows the estimation of regional cerebral blood flow without requiring the administration of radioligands or contrast agents. Thus, ASL is well suited for within-subject longitudinal designs (eg, to study evolution of pain states over time, or of treatment effects in clinical trials). Arterial spin labeling is also highly versatile, allowing for novel paradigms exploring a flexible array of pain states, plus it can be used to simultaneously estimate not only pain-related alterations in perfusion but also functional connectivity. In conclusion, ASL can be successfully applied in pain paradigms that would be either challenging or impossible to implement using other techniques. Particularly when used in concert with other neuroimaging techniques, ASL can be a powerful tool in the pain imager's toolbox." @default.
- W2969156734 created "2019-08-22" @default.
- W2969156734 creator A5035274081 @default.
- W2969156734 creator A5040446907 @default.
- W2969156734 creator A5067938667 @default.
- W2969156734 creator A5079014471 @default.
- W2969156734 date "2019-07-01" @default.
- W2969156734 modified "2023-10-18" @default.
- W2969156734 title "Imaging clinically relevant pain states using arterial spin labeling" @default.
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