FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969174611> ?p ?o ?g. }

• W2969174611 endingPage "14" @default.
• W2969174611 startingPage "1" @default.
• W2969174611 abstract "Oxidative stress is a consequence of the use of oxygen in aerobic respiration by living organisms and is denoted as a persistent condition of an imbalance between the generation of reactive oxygen species (ROS) and the ability of the endogenous antioxidant system (AOS) to detoxify them. The oxidative stress theory has been confirmed in many animal studies, which demonstrated that the maintenance of cellular homeostasis and biomolecular stability and integrity is crucial for cellular longevity and successful aging. Mitochondrial dysfunction, impaired protein homeostasis (proteostasis) network, alteration in the activities of transcription factors such as Nrf2 and NF- κ B, and disturbances in the protein quality control machinery that includes molecular chaperones, ubiquitin-proteasome system (UPS), and autophagy/lysosome pathway have been observed during aging and age-related chronic diseases. The accumulation of ROS under oxidative stress conditions results in the induction of lipid peroxidation and glycoxidation reactions, which leads to the elevated endogenous production of reactive aldehydes and their derivatives such as glyoxal, methylglyoxal (MG), malonic dialdehyde (MDA), and 4-hydroxy-2-nonenal (HNE) giving rise to advanced lipoxidation and glycation end products (ALEs and AGEs, respectively). Both ALEs and AGEs play key roles in cellular response to oxidative stress stimuli through the regulation of a variety of cell signaling pathways. However, elevated ALE and AGE production leads to protein cross-linking and aggregation resulting in an alteration in cell signaling and functioning which causes cell damage and death. This is implicated in aging and various age-related chronic pathologies such as inflammation, neurodegenerative diseases, atherosclerosis, and vascular complications of diabetes mellitus. In the present review, we discuss experimental data evidencing the impairment in cellular functions caused by AGE/ALE accumulation under oxidative stress conditions. We focused on the implications of ALEs/AGEs in aging and age-related diseases to demonstrate that the identification of cellular dysfunctions involved in disease initiation and progression can serve as a basis for the discovery of relevant therapeutic agents." @default.
• W2969174611 created "2019-08-22" @default.
• W2969174611 creator A5056453113 @default.
• W2969174611 creator A5058166043 @default.
• W2969174611 creator A5059310084 @default.
• W2969174611 creator A5064672958 @default.
• W2969174611 creator A5068856878 @default.
• W2969174611 date "2019-08-14" @default.
• W2969174611 modified "2023-10-10" @default.
• W2969174611 title "Oxidative Stress and Advanced Lipoxidation and Glycation End Products (ALEs and AGEs) in Aging and Age-Related Diseases" @default.
• W2969174611 cites W110955121 @default.
• W2969174611 cites W15885275 @default.
• W2969174611 cites W1591649477 @default.
• W2969174611 cites W1853148353 @default.
• W2969174611 cites W1869566076 @default.
• W2969174611 cites W1965891907 @default.
• W2969174611 cites W1969413427 @default.
• W2969174611 cites W1972459018 @default.
• W2969174611 cites W1972647829 @default.
• W2969174611 cites W1972773471 @default.
• W2969174611 cites W1972958434 @default.
• W2969174611 cites W1975044301 @default.
• W2969174611 cites W1975608441 @default.
• W2969174611 cites W1976474010 @default.
• W2969174611 cites W1978297210 @default.
• W2969174611 cites W1980927269 @default.
• W2969174611 cites W1983092847 @default.
• W2969174611 cites W1984036841 @default.
• W2969174611 cites W1986413832 @default.
• W2969174611 cites W1986562862 @default.
• W2969174611 cites W1987796811 @default.
• W2969174611 cites W1993071111 @default.
• W2969174611 cites W1998990072 @default.
• W2969174611 cites W2000038034 @default.
• W2969174611 cites W2001257710 @default.
• W2969174611 cites W2002424969 @default.
• W2969174611 cites W2008124325 @default.
• W2969174611 cites W2011382030 @default.
• W2969174611 cites W2011454946 @default.
• W2969174611 cites W2011997519 @default.
• W2969174611 cites W2014881030 @default.
• W2969174611 cites W2015008845 @default.
• W2969174611 cites W2018427433 @default.
• W2969174611 cites W2019898105 @default.
• W2969174611 cites W2019956561 @default.
• W2969174611 cites W2023497842 @default.
• W2969174611 cites W2023695511 @default.
• W2969174611 cites W2026517317 @default.
• W2969174611 cites W2027183895 @default.
• W2969174611 cites W2031280853 @default.
• W2969174611 cites W2033501232 @default.
• W2969174611 cites W2036229829 @default.
• W2969174611 cites W2036704550 @default.
• W2969174611 cites W2037297543 @default.
• W2969174611 cites W2037880347 @default.
• W2969174611 cites W2039374791 @default.
• W2969174611 cites W2041290559 @default.
• W2969174611 cites W2042667331 @default.
• W2969174611 cites W2043460275 @default.
• W2969174611 cites W2045418941 @default.
• W2969174611 cites W2050500616 @default.
• W2969174611 cites W2052644645 @default.
• W2969174611 cites W2054835938 @default.
• W2969174611 cites W2056309306 @default.
• W2969174611 cites W2058052005 @default.
• W2969174611 cites W2059737503 @default.
• W2969174611 cites W2060006939 @default.
• W2969174611 cites W2063526462 @default.
• W2969174611 cites W2068986375 @default.
• W2969174611 cites W2069923068 @default.
• W2969174611 cites W2071193713 @default.
• W2969174611 cites W2071205491 @default.
• W2969174611 cites W2076769172 @default.
• W2969174611 cites W2077215912 @default.
• W2969174611 cites W2078697962 @default.
• W2969174611 cites W2082425146 @default.
• W2969174611 cites W2099783988 @default.
• W2969174611 cites W2103747277 @default.
• W2969174611 cites W2106216311 @default.
• W2969174611 cites W2108762011 @default.
• W2969174611 cites W2112937322 @default.
• W2969174611 cites W2114064075 @default.
• W2969174611 cites W2115817059 @default.
• W2969174611 cites W2117114474 @default.
• W2969174611 cites W2122341467 @default.
• W2969174611 cites W2124748470 @default.
• W2969174611 cites W2126525177 @default.
• W2969174611 cites W2129852694 @default.
• W2969174611 cites W2132886980 @default.
• W2969174611 cites W2136497849 @default.
• W2969174611 cites W2137471813 @default.
• W2969174611 cites W2138443291 @default.
• W2969174611 cites W2138928713 @default.
• W2969174611 cites W2141862955 @default.
• W2969174611 cites W2144013753 @default.
• W2969174611 cites W2146383544 @default.
• W2969174611 cites W2146857090 @default.
• W2969174611 cites W2150136458 @default.

• next