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- W2969181388 abstract "Significance By performing a targeted genetic screen of temperature-sensitive mutations, this study identified 94 essential Saccharomyces cerevisiae genome instability suppressing (eGIS) genes and 38 candidate eGIS genes. Analysis of The Cancer Genome Atlas data demonstrated that mutations in the human homologues of the S. cerevisiae eGIS genes were significantly enriched in 10 different human cancers. These results provide insights into the origin of genome instability in human cancers and provide tools for identifying and evaluating mutations that contribute to the development of cancer." @default.
- W2969181388 created "2019-08-22" @default.
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- W2969181388 date "2019-08-13" @default.
- W2969181388 modified "2023-09-26" @default.
- W2969181388 title "Essential <i>Saccharomyces cerevisiae</i> genome instability suppressing genes identify potential human tumor suppressors" @default.
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- W2969181388 doi "https://doi.org/10.1073/pnas.1906921116" @default.
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