FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969181812> ?p ?o ?g. }

• W2969181812 endingPage "1993" @default.
• W2969181812 startingPage "1986" @default.
• W2969181812 abstract "Several studies have identified potential roles for MFG-E8 in promoting tissue repair. However, the effects of MFG-E8 on tendon repair have not yet been investigated. Therefore, we explored the role of MFG-E8 on tendon repair using a rat model of patellar tendon injury. The patellar tendons of Sprague Dawley rats (n = 24/group) received window defects and, after modeling, three groups were randomly assigned: (a) recombinant MFG-E8 (rMFG-E8) group, implantation with MFG-E8 and fibrin glue (400 ng in 10 μl); (b) fibrin group, implantation with fibrin only; and (c) control group, without any treatment. Histopathology, immunohistochemistry, and gene expression analyses were performed at 2 and 4 weeks after healing. Administration of rMFG-E8 in injury sites significantly improved tendon healing histologically at 4 weeks after injury. In addition, numbers of M1 macrophages and M1-stimulator genes, including IFNG, Il-1B, and Il-6, were reduced in the repair sites at 2 weeks by rMFG-E8 administration. In parallel, rMFG-E8 significantly increased the number of M2 macrophages and expression of anti-inflammatory IL-10 and IL-4 at 2 weeks after injury. Treatment with rMFG-E8 markedly decreased tendon cell apoptosis. Moreover, rMFG-E8 significantly enhanced the expression of genes related to tendon matrix formation at 2 weeks after injury, including Col1a1and tenascin-C. We conclude that MFG-E8 could regulate inflammatory responses and apoptotic cell accumulation in tendon repair, and promote the healing process of injured tendon tissue. Thus, exogenous application of MFG-E8 might have therapeutic potential for repair of tendon injuries." @default.
• W2969181812 created "2019-08-22" @default.
• W2969181812 creator A5005039268 @default.
• W2969181812 creator A5007520410 @default.
• W2969181812 creator A5011276376 @default.
• W2969181812 creator A5050946904 @default.
• W2969181812 date "2019-08-13" @default.
• W2969181812 modified "2023-10-14" @default.
• W2969181812 title "MFG‐E8 regulates inflammation and apoptosis in tendon healing, and promotes tendon repair: A histological and biochemical evaluation" @default.
• W2969181812 cites W1500187154 @default.
• W2969181812 cites W1516501789 @default.
• W2969181812 cites W1786980 @default.
• W2969181812 cites W1963267789 @default.
• W2969181812 cites W2027878490 @default.
• W2969181812 cites W2042142931 @default.
• W2969181812 cites W2063616711 @default.
• W2969181812 cites W2090584945 @default.
• W2969181812 cites W2154867093 @default.
• W2969181812 cites W2166648746 @default.
• W2969181812 cites W2174617543 @default.
• W2969181812 cites W2403287989 @default.
• W2969181812 cites W2536186400 @default.
• W2969181812 cites W2590906681 @default.
• W2969181812 cites W2592627896 @default.
• W2969181812 cites W2597723853 @default.
• W2969181812 cites W2615122884 @default.
• W2969181812 cites W2619375165 @default.
• W2969181812 cites W2730805193 @default.
• W2969181812 cites W2790502540 @default.
• W2969181812 cites W2805329598 @default.
• W2969181812 cites W2883501038 @default.
• W2969181812 cites W2885812216 @default.
• W2969181812 cites W2887831957 @default.
• W2969181812 cites W2909702975 @default.
• W2969181812 cites W2954174412 @default.
• W2969181812 doi "https://doi.org/10.1002/iub.2143" @default.
• W2969181812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31408279" @default.
• W2969181812 hasPublicationYear "2019" @default.
• W2969181812 type Work @default.
• W2969181812 sameAs 2969181812 @default.
• W2969181812 citedByCount "5" @default.
• W2969181812 countsByYear W29691818122019 @default.
• W2969181812 countsByYear W29691818122021 @default.
• W2969181812 countsByYear W29691818122022 @default.
• W2969181812 countsByYear W29691818122023 @default.
• W2969181812 crossrefType "journal-article" @default.
• W2969181812 hasAuthorship W2969181812A5005039268 @default.
• W2969181812 hasAuthorship W2969181812A5007520410 @default.
• W2969181812 hasAuthorship W2969181812A5011276376 @default.
• W2969181812 hasAuthorship W2969181812A5050946904 @default.
• W2969181812 hasBestOaLocation W29691818121 @default.
• W2969181812 hasConcept C141071460 @default.
• W2969181812 hasConcept C142724271 @default.
• W2969181812 hasConcept C16685009 @default.
• W2969181812 hasConcept C171056886 @default.
• W2969181812 hasConcept C190283241 @default.
• W2969181812 hasConcept C203014093 @default.
• W2969181812 hasConcept C2776914184 @default.
• W2969181812 hasConcept C2780105995 @default.
• W2969181812 hasConcept C2780269544 @default.
• W2969181812 hasConcept C54173615 @default.
• W2969181812 hasConcept C544855455 @default.
• W2969181812 hasConcept C55493867 @default.
• W2969181812 hasConcept C71924100 @default.
• W2969181812 hasConcept C86803240 @default.
• W2969181812 hasConcept C95444343 @default.
• W2969181812 hasConceptScore W2969181812C141071460 @default.
• W2969181812 hasConceptScore W2969181812C142724271 @default.
• W2969181812 hasConceptScore W2969181812C16685009 @default.
• W2969181812 hasConceptScore W2969181812C171056886 @default.
• W2969181812 hasConceptScore W2969181812C190283241 @default.
• W2969181812 hasConceptScore W2969181812C203014093 @default.
• W2969181812 hasConceptScore W2969181812C2776914184 @default.
• W2969181812 hasConceptScore W2969181812C2780105995 @default.
• W2969181812 hasConceptScore W2969181812C2780269544 @default.
• W2969181812 hasConceptScore W2969181812C54173615 @default.
• W2969181812 hasConceptScore W2969181812C544855455 @default.
• W2969181812 hasConceptScore W2969181812C55493867 @default.
• W2969181812 hasConceptScore W2969181812C71924100 @default.
• W2969181812 hasConceptScore W2969181812C86803240 @default.
• W2969181812 hasConceptScore W2969181812C95444343 @default.
• W2969181812 hasFunder F4320309612 @default.
• W2969181812 hasFunder F4320321001 @default.
• W2969181812 hasIssue "12" @default.
• W2969181812 hasLocation W29691818121 @default.
• W2969181812 hasLocation W29691818122 @default.
• W2969181812 hasOpenAccess W2969181812 @default.
• W2969181812 hasPrimaryLocation W29691818121 @default.
• W2969181812 hasRelatedWork W2312560553 @default.
• W2969181812 hasRelatedWork W2399761608 @default.
• W2969181812 hasRelatedWork W2474283336 @default.
• W2969181812 hasRelatedWork W2518593564 @default.
• W2969181812 hasRelatedWork W2884893653 @default.
• W2969181812 hasRelatedWork W3039419443 @default.
• W2969181812 hasRelatedWork W3173267049 @default.
• W2969181812 hasRelatedWork W4233888466 @default.
• W2969181812 hasRelatedWork W4386772532 @default.
• W2969181812 hasRelatedWork W611855264 @default.

• next