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• W2969183784 abstract "Abstract The eye-gaze of others is a prominent social cue in primates and crucial for communication 1-7 , and atypical processing occurs in several conditions as autism-spectrum-disorder (ASD) 1,9-14 . The neural mechanisms that underlie eye-gaze remain vague, and it is still debated if these computations developed in dedicated neural circuits or shared with non-social elements. In many species, eye-gaze signals a threat and elicits anxiety, yet can also serve as a predictor for the outcome of the encounter: negative or positive 2,4,8 . Here, we hypothesized and find that neural codes overlap between eye-gaze and valence. Monkeys participated in a modified version of the human-intruder-test 8,15 that includes direct and averted eye-gaze and interleaved with blocks of aversive and appetitive conditioning 16,17 . We find that single-neurons in the amygdala encode gaze 18 , whereas neurons in the anterior-cingulate-cortex encode the social context 19,20 but not gaze. We identify a shared amygdala circuitry where neural responses to averted and direct gaze parallel the responses to appetitive and aversive value, correspondingly. Importantly, we distinguish two shared coding mechanisms: a shared-intensity scheme that is used for gaze and the unconditioned-stimulus, and a shared-activity scheme that is used for gaze and the conditioned-stimulus. The shared-intensity points to overlap in circuitry, whereas the shared-activity requires also correlated activity. Our results demonstrate that eye-gaze is coded as a signal of valence, yet also as the expected value of the interaction. The findings may suggest new insights into the mechanisms that underlie the malfunction of eye-gaze in ASD and the comorbidity with impaired social skills and anxiety." @default.
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• W2969183784 date "2019-08-15" @default.
• W2969183784 modified "2023-10-18" @default.
• W2969183784 title "Shared neural codes for eye-gaze and valence" @default.
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• W2969183784 doi "https://doi.org/10.1101/736462" @default.
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