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• W2969197997 abstract "Active-site directed probes are powerful tools for studying the ubiquitin conjugation and deconjugation machinery. Branched ubiquitin chains have emerged as important proteasome-targeting signals for aggregation-prone proteins and cell cycle regulators. By implementing a new synthetic strategy for the electrophilic warhead, we herein report on the generation and reactivity of a series of branched triubiquitin active-site directed probes. These new tools can be used to dissect the molecular basis of branched chain assembly and disassembly." @default.
• W2969197997 created "2019-08-22" @default.
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• W2969197997 date "2019-08-09" @default.
• W2969197997 modified "2023-10-14" @default.
• W2969197997 title "Synthesis of Branched Triubiquitin Active-Site Directed Probes" @default.
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• W2969197997 doi "https://doi.org/10.1021/acs.orglett.9b02406" @default.
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