FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969235561> ?p ?o ?g. }

• W2969235561 endingPage "125" @default.
• W2969235561 startingPage "125" @default.
• W2969235561 abstract "<ns3:p><ns3:bold>Introduction:</ns3:bold> Cardiometabolic factors are implicated in the aetiology of Alzheimer’s disease and may lie on the pathways linking genetic variants to Alzheimer’s disease across the life course. We examined whether polygenic risk scores (PRS) were associated with cardiometabolic health indicators through childhood and adolescence.</ns3:p><ns3:p> <ns3:bold>Methods: </ns3:bold>In 7,977 participants from the Avon Longitudinal Study of Parents and Children, we tested whether a PRS for Alzheimer’s disease was associated with trajectories of cardiometabolic risk factors. We examined trajectories for height at 1-18 years; lean and fat mass at 9-18 years; systolic and diastolic blood pressure at 7-18 years; glucose and C-reactive protein at 9-18 years; insulin at 10-18 years; and high and low-density lipoproteins and triglycerides birth at 18 years. We also examined birthweight and interleukin-6 (IL-6) at age 9 years and physical activity at ages 11, 12, and 15 years.</ns3:p><ns3:p> <ns3:bold>Results: </ns3:bold>No consistent associations were observed between the PRS excluding genetic variants in the apolipoprotein E gene region and cardiometabolic factors trajectories across childhood and adolescence.</ns3:p><ns3:p> <ns3:bold>Conclusions: </ns3:bold>We did not detect evidence to suggest that the PRS for Alzheimer’s disease acts through childhood and adolescent cardiometabolic risk factors. Further studies should examine whether these associations emerge later in adulthood when variation in cardiometabolic risk factors is likely to be greater.</ns3:p>" @default.
• W2969235561 created "2019-08-29" @default.
• W2969235561 creator A5013184354 @default.
• W2969235561 creator A5015920377 @default.
• W2969235561 creator A5032548714 @default.
• W2969235561 creator A5039977438 @default.
• W2969235561 creator A5061906916 @default.
• W2969235561 creator A5083848260 @default.
• W2969235561 creator A5088672891 @default.
• W2969235561 date "2019-08-20" @default.
• W2969235561 modified "2023-10-14" @default.
• W2969235561 title "Polygenic risk score for Alzheimer’s disease and trajectories of cardiometabolic risk factors in children" @default.
• W2969235561 cites W1453510387 @default.
• W2969235561 cites W1783439519 @default.
• W2969235561 cites W1871783318 @default.
• W2969235561 cites W1875461135 @default.
• W2969235561 cites W1884189242 @default.
• W2969235561 cites W1970690591 @default.
• W2969235561 cites W1988761237 @default.
• W2969235561 cites W1995709472 @default.
• W2969235561 cites W2001052319 @default.
• W2969235561 cites W2025651303 @default.
• W2969235561 cites W2036362108 @default.
• W2969235561 cites W2074661773 @default.
• W2969235561 cites W2096601431 @default.
• W2969235561 cites W2098597355 @default.
• W2969235561 cites W2106611664 @default.
• W2969235561 cites W2110924846 @default.
• W2969235561 cites W2114063969 @default.
• W2969235561 cites W2115779804 @default.
• W2969235561 cites W2119855286 @default.
• W2969235561 cites W2121101037 @default.
• W2969235561 cites W2123263006 @default.
• W2969235561 cites W2130945157 @default.
• W2969235561 cites W2133098270 @default.
• W2969235561 cites W2143509157 @default.
• W2969235561 cites W2147254563 @default.
• W2969235561 cites W2149792754 @default.
• W2969235561 cites W2193207784 @default.
• W2969235561 cites W2293040502 @default.
• W2969235561 cites W2512788553 @default.
• W2969235561 cites W2751468214 @default.
• W2969235561 cites W2759588044 @default.
• W2969235561 cites W2803051479 @default.
• W2969235561 cites W2807749226 @default.
• W2969235561 cites W2894404475 @default.
• W2969235561 cites W2909753179 @default.
• W2969235561 cites W2969235561 @default.
• W2969235561 doi "https://doi.org/10.12688/wellcomeopenres.15359.1" @default.
• W2969235561 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6971849" @default.
• W2969235561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31984241" @default.
• W2969235561 hasPublicationYear "2019" @default.
• W2969235561 type Work @default.
• W2969235561 sameAs 2969235561 @default.
• W2969235561 citedByCount "5" @default.
• W2969235561 countsByYear W29692355612019 @default.
• W2969235561 countsByYear W29692355612021 @default.
• W2969235561 countsByYear W29692355612022 @default.
• W2969235561 countsByYear W29692355612023 @default.
• W2969235561 crossrefType "journal-article" @default.
• W2969235561 hasAuthorship W2969235561A5013184354 @default.
• W2969235561 hasAuthorship W2969235561A5015920377 @default.
• W2969235561 hasAuthorship W2969235561A5032548714 @default.
• W2969235561 hasAuthorship W2969235561A5039977438 @default.
• W2969235561 hasAuthorship W2969235561A5061906916 @default.
• W2969235561 hasAuthorship W2969235561A5083848260 @default.
• W2969235561 hasAuthorship W2969235561A5088672891 @default.
• W2969235561 hasBestOaLocation W29692355611 @default.
• W2969235561 hasConcept C126322002 @default.
• W2969235561 hasConcept C142724271 @default.
• W2969235561 hasConcept C2777895361 @default.
• W2969235561 hasConcept C71924100 @default.
• W2969235561 hasConcept C84393581 @default.
• W2969235561 hasConceptScore W2969235561C126322002 @default.
• W2969235561 hasConceptScore W2969235561C142724271 @default.
• W2969235561 hasConceptScore W2969235561C2777895361 @default.
• W2969235561 hasConceptScore W2969235561C71924100 @default.
• W2969235561 hasConceptScore W2969235561C84393581 @default.
• W2969235561 hasFunder F4320307874 @default.
• W2969235561 hasFunder F4320312938 @default.
• W2969235561 hasFunder F4320319992 @default.
• W2969235561 hasFunder F4320320360 @default.
• W2969235561 hasFunder F4320332161 @default.
• W2969235561 hasFunder F4320334626 @default.
• W2969235561 hasLocation W29692355611 @default.
• W2969235561 hasLocation W29692355612 @default.
• W2969235561 hasLocation W29692355613 @default.
• W2969235561 hasLocation W29692355614 @default.
• W2969235561 hasLocation W29692355615 @default.
• W2969235561 hasLocation W29692355616 @default.
• W2969235561 hasLocation W29692355617 @default.
• W2969235561 hasOpenAccess W2969235561 @default.
• W2969235561 hasPrimaryLocation W29692355611 @default.
• W2969235561 hasRelatedWork W1977660421 @default.
• W2969235561 hasRelatedWork W209113707 @default.
• W2969235561 hasRelatedWork W2099514316 @default.
• W2969235561 hasRelatedWork W2165023468 @default.
• W2969235561 hasRelatedWork W2888170609 @default.

• next